Personal profile
In Korean
이동석 교수(자연과학대학 생명공학부)
Education
o (1994) B.A., Kyungpook National University, Daegu, Korea
o (1997) M.A., The University of Tokyo, Tokyo , Japan
o (2000) Ph.D., The University of Tokyo, Tokyo , Japan
o (1997) M.A., The University of Tokyo, Tokyo , Japan
o (2000) Ph.D., The University of Tokyo, Tokyo , Japan
Professional Experience
o (2007~Present) Professor, Kyungpook National University, Daegu, Korea
o (2020~Present) Director, BK21 FOUR KNU Creative BioResearch Group, Daegu, Korea
o (2014~2020) Director, BK21 Plus KNU Creative BioResearch Group, Daegu, Korea
o (2006~2007) Assistant Professor, Kangwon National University, Chuncheon, Korea
o (2002~2006) Senior Researcher, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
o (2000~2001) Visiting researcher, National Institutes of Health, NC, USA
o (2020~Present) Director, BK21 FOUR KNU Creative BioResearch Group, Daegu, Korea
o (2014~2020) Director, BK21 Plus KNU Creative BioResearch Group, Daegu, Korea
o (2006~2007) Assistant Professor, Kangwon National University, Chuncheon, Korea
o (2002~2006) Senior Researcher, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
o (2000~2001) Visiting researcher, National Institutes of Health, NC, USA
Research Interests
Neuroscience, Neurodegenrative diseases, Alzheimer's Disease, Multiple scleroisis, Neural cells, Glial cells, Mitochondria, Mitochondrial dynamics, Organelle, Inflammation, Obesity, Antioxidants, Peroxiredoxins, Reactive Oxygen Species, Animal models
Major Research Achievements
o Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways
o Mitochondrial dynamics modulate the expression of pro‐inflammatory mediators in microglial cells
o Enhancement of target specificity of CRISPR–Cas12a by using a chimeric DNA–RNA guide
o Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling
o Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus
o Mitochondrial dynamics modulate the expression of pro‐inflammatory mediators in microglial cells
o Enhancement of target specificity of CRISPR–Cas12a by using a chimeric DNA–RNA guide
o Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling
o Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus
url
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics where Dong-Seok Lee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Directed evolution on compact landing pads yields highly efficient recombinases for large DNA integration
Kim, H., Kang, H. G., Oh, Y., Lee, W. J., Lee, Y., Kim, E. K., Nam, K. H., Lee, D. S., Lee, S. H. & Sim, B. W., 13 Jan 2026, In: Nucleic Acids Research. 54, 1, gkaf1444.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cells
Kim, Y. H., Kim, J. B., Bae, J. E., Park, N. Y., Kim, S. H., Um, J. Y., Lee, D. S., Lee, K. S., Kim, P. K., Jo, D. S. & Cho, D. H., 2026, In: Autophagy. 22, 2, p. 316-329 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage
Park, N. Y., Jo, D. S., Yang, J. Y., Bae, J. E., Kim, J. B., Kim, Y. H., Kim, S. H., Kim, P., Lee, D. S., Yoshimori, T., Jo, E. K., Yeom, E. & Cho, D. H., Dec 2025, In: Nature Communications. 16, 1, 1109.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Ataxin-3 Overexpression via Adeno-associated Viral Vector Injection in the Primate Cerebellum: A Novel Model of Spinocerebellar Ataxia Type 3
Kim, K., Kim, A., Won, J., Park, J., Lim, K. S., Jeon, C. Y., Min, J., Cho, J. H., Song, Y., Koo, B. S., Bae, G. S., Jeon, E., Jeong, K. J., Park, S. H., Lee, H. Y., Choi, W. S., Lee, D. S. & Lee, Y., Jan 2025, In: Experimental Neurobiology. 34, 6, p. 248-262 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Combined effect of probiotics and omega-3 fatty acids on blood and liver function biomarkers and gut microbiota diversity in male mice with high fat diet-induced obesity
Son, K. H., Lee, J., Yang, H. Y., Heo, Y., Lee, J. S., Lee, D. S., Shin, K. J. & Kwon, T. J., Sep 2025, In: PLoS ONE. 20, 9 September, e0331981.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations