류홍열 교수(자연과학대학 생명공학부)

o (2009) B.S., Hanyang University ERICA, Korea
o (2015) Ph.D., Hanyang University, Korea

o (2000~Present) Assistant Professor, Kyungpook National University, Daegu, Korea
o (2019~2020) Research Professor, Hanyang University ERICA, Ansan, Korea
o (2015~2019) Postdoctoral Associate, Yale University, New Haven, USA
o (2015~2015) Post Doctor, Hanyang University ERICA, Ansan, Korea

The small ubiquitin-like modifier (SUMO) protein, which is evolutionarily conserved and found in all eukaryotes, post-translationally modifies diverse substrates involved in various cellular processes, including transcription, DNA replication, cell cycle progression, nucleo-cytoplasmic transport, apoptosis, and genome stability. To uncover the biochemical activities and biological functions of SUMO modification, we have been working on SUMO function in epigenetics, cellular aging, and adaptive mechanism.

o Histone Sumoylation Promotes Set3 Histone-Deacetylase Complex-Mediated Transcriptional Regulation. Nucleic Acids Research, 2020
o The Ulp2 SUMO Protease Promotes Transcription Elongation through Regulation of Histone Sumoylation. EMBO Journal, 2019
o Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease. Nature Communications, 2018
o Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development, 2016
o Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biology, 2014

https://sites.google.com/view/knu-lme/