신준철 교수(생태환경대학 체육학부)

o (2007) B.S. Sungkyunkwan University College of Sports Science, Republic of Korea
o (2009) M.S. Sungkyunkwan University College of Sports Science, Republic of Korea
o (2015) Ph.D Tohoku University, School of Medicine, Department of Medicine and Science in Sports and Exercise, Japan

o [2024 – present] Department of Kinesiology, Kyungpook National University
o [2022 - 2024] Research Associate. Cleveland Clinic Lerner Research Institute
o [2021 - 2022] Postdoctoral Fellow. Cleveland Clinic Lerner Research Institute
o [2016 - 2020] Postdoctoral Fellow. Temple University

My primary research effort focus on 1) cardiovascular function in various pathophysiological conditions, 2) the crosstalk between endothelial cell and skeletal muscle cell in vascular disease and 3) the molecular alteration of endothelial mitochondria function underlying muscle-derived secreted cytokine or proteins in atherosclerosis. Last few decades, lack of physical activity and western-style diet has become the main risk factor for cardiovascular diseases. Exercise and increased skeletal muscle mass are closely associated with the lower incidence of cardiovascular mortality. However, the role of communication between endothelial cell and skeletal muscle cell in vascular health has not been fully understood. Consequently, the understanding of mechanism by which skeletal muscle cells can prevent vascular function in various cardiovascular disease might be critical to provide new insight to prevent vascular diseases. Eventually, my long-term goal is to be an independent investigator in field of vascular biology.

1. Junyoung Hong, Junchul Shin. Prolonged Hypoxic Exposure Impairs Endothelial Functions: Possible Mechanism of HIF-1α Signaling. Exercise Science Vol.33, No. 2, May 2024: 168-175

2. Aatish Mahajan, Junyoung Hong, Irene Krukovets, Junchul Shin, Svyatoslav Tkachenko, Cristina Espinosa-Diez, Gary K. Owens, Olga A. Cherepanova. Integrative analysis of the lncRNA-miRNA-mRNA Interactions in Smooth Muscle Cell Phenotypic Transitions. Frontier in Genetics Vol. 15 April 2024.

3. C. Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari, Kalash Neupane, Mariam R Khan, Esther Opoku, Emmanuel Opoku, Gregory Brubaker, Junchul Shin, Junyoung Hong, Kanuri Nageshwar, Elif G. Ertugra, Prabhakara R Nagareddy, Chandrasekhar R. Kothapalli, Olga Cherepanova, Jonathan D. Smith, and Kailash Gulshan. Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice. The Journal of the American Heart Association (JAHA) Volume 13 Number 8, April 2024.

4. Junchul Shin. The Prolyl hydroxylase domain 2 (PHD2) deficiency enhances maximal exercise capacity. Exercise Science Vol.33, No. 1, February 2024: 57-63.

5. Junchul Shin, Junyoung Hong, Jonnelle Edwards-Glenn, Irene Krukovets, Svyatoslav Tkachenko, Maria L. Adelus, Casey E. Romanoski, Sanjay Rajagopalan, Eugene Podrez, Tatiana V. Byzova, Olga Stenina-Adongravi, Olga A. Cherepanova. Unraveling the Role of Sex in Endothelial Cell Dysfunction – Evidence from Lineage Tracing Mice and Cultured Cells. Atherosclerosis, Thrombosis and Vascular Biology Vol 11. No 1 (2023)

6. Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K. Owens, Olga A. Cherepanova. SMC-specific loss of OCT4 accelerates neointima formation after acute vascular injury. Frontier in Cardiovascular Medicine Volume 10 2023.

7. Jinkyung Cho, Bruce D Johnson, Kymberly D. Watt, Alexander S. Niven, Junchul Shin, Chul-Ho Kim. Alterations in Pulmonary Vasomotor Modulators Post Aerobic Exercise Training in Non-Alcoholic Fatty Liver Disease. Respiratory Physiology & Neurobiology 314 (2023) 104089.

8. Junchul Shin, Aki Nunomiya, Kohsuke Gonda, Ryoichi Nagatomi. Specification of skeletal muscle fiber-type is determined by the calcineurin/NFATc1 signaling pathway during muscle regeneration. Biochemical and Biophysical Research Communications. 659 (2023) 20-28.

9. Soon-Gook Hong, Junchul Shin, Soo Young Choi, Jeffery C. Powers, Jacqueline Sayoc, Jun Seok Son, Ryan Tierney, Fabio A. Recchia, Michael D. Brown, Xiaofeng Yang, and Joon-Young Park. Flow pattern–dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells. Volume 7, Issue 18 on September 22, 2022, JCI Insight. 2022;7(18):e159286.

10. Junchul Shin*, Svyatoslav Tkachenko*, Malay Chaklader*, Connor Pletz, Kanwardeep Singh, Gamze B Bulut, Young min Han, Kelly Mitchell, Richard A Baylis, Andrey A Kuzmin, Bo Hu, Justin D Lathia, Olga Stenina-Adognravi, Eugene Podrez, Tatiana V Byzova, Gary K Owens, Olga A Cherepanova. Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction. Cardiovascular Research, Volume 118, Issue 11, July 2022, Pages 2458–2477.
*Co-first author

11. Junchul Shin*, Soon-Gook Hong*, Soo Young Choi, Meghan E. Rath, Hye-Sang Park, Jason Saredy, Satoru Eguchi, Victor Rizzo, Rosario Scalia, Hong Wang, Steven R. Houser, Joon-Young Park. Flow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner, Redox Biology vol. 50 (2022).
*Co-first author

12. Benjamin M. Meister, Soon-Gook Hong, Junchul Shin, Meghan Rath, Jacqueline Sayoc, and Joon-Young Park. Healthy vs. Unhealthy Adipose Tissue Expansion: The Role of Exercise. Journal of Obesity & Metabolic Syndrome (2022)

13. Soon-Gook Hong, Junchul Shin, Maitha Aldokhayyil, Michael David Brown, and Joon-Young Park. Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells. Exercise Sports Science Reviews. (2022).

14. Salamah A, Junchul Shin, Park JY, Effect of NSAIDs on muscle adaptations to resistance training: A Brief Review, Journal of Public Health Issues and Practices, (2019), JPHIP-132

15. Hojun Lee, Kijeong Kim, Boa Kim, Junchul Shin, Sudarsan Rajan, Jingwei, Wu, Xiongwen Chen, Michael D. Brown, Sunkho Lee, and Joon-Young Park. A cellular mechanism of muscle memory facilitates mitochondrial remodeling following resistance training. Journal of Physiology. 2018 Sep;596(18):4413-4426.

16. Aki Nunomiya*, Junchul Shin*, Yasuo Kitajima, Takashi Dan, Toshio Miyata, Ryoichi Nagatomi. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiologica (2017), 220, 99-112.
*Co-first author

17. Junchul Shin*, Aki Nunomiya*, Yasuo Kitajima, Takashi Dan, Toshio Miyata, Ryoichi Nagatomi. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skeletal Muscle (2016) 6:5.
*Co-first author