백문창 교수(의과대학 의학과)

o (1991) B.S., ChungNam National University, Daejeon
o (1994) M.S., Seoul National University, Seoul, Korea
o (1997) Ph.D., Seoul National University, Seoul, Korea

o (2005~Present) Assistant/Associate/Professor, Department of Molecular Medicine, School of Medicine, KNU
o (2012~2013) Visiting Professor, Dept. of Chemical Physiology, The Scripps Research Institute, La Jolla, USA
o (2002~2005) Research Assistant Professor, Division of Molecular and Life Sciences, POSTECH, Pohang, Korea
o (1998~2002) Post doctoral research fellow, Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, USA

o Characterization of mechanism for cancer metastasis based on exosomes (biological nano-material) o Development of oral exosomes for cancer immunotherapy
o Identification of biomarkers related to various cancers using exosomal proteins
o Development of drug candidate targeting to exosomes secretion

o Dissecting exosome inhibitors: Therapeutic insights on the small-molecule chemicals against cancer, Exp Mol Med. 2022 Nov;54(11):1833-1843. (IF=12.8)
o Novel antitumor therapeutic strategy using CD4+ T cell-derived extracellular vesicles Biomaterials. 2022 Oct;289:121765. (IF=14.0)
o Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1, Theranostics. 2022 Jan 31;12(5):1971-1987. (IF=12.4)
o Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1, Adv Sci (Weinh). 2022 Feb;9(5):e2103245. Epub 2021 Dec 20. (IF=15.1)
o Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387. doi: 10.1038/s41467-019-09387-4. (IF=16.6)

http://exosome.knu.ac.kr/lab/