이유미 교수(약학대학 약학과)

o (1985) B.A., Seoul National University, College of Pharmacy
o (1987) M.A., Seoul National University, College of Pharmacy
o (1996) Ph.D., Seoul National University, College of Pharmacy

o (2024-2025) President, Korean Society of Vascular Biology and Medicine
o (2020-2027) Director, MRC (Vessel-Organ Interaction Research Center)
o (2019-2023) Vice president, Korean Society of Vascular Biology and Medicine
o (2020- ) Fellow, Korea Academy of Science and Technology
o (2019-2022) Member, NRF Policy Advisory Committee,
o (2016- ) Vice president, The Pharmaceutical Society of Korea,
o (2016-2017) Vice President, International Affairs, KNU
o (2013-2017) PI, Vascular Homeostasis Regulation Lab (BRL)
o (2013-2015 & 2022-2023) Dean, Kyungpook National University, College of Pharmacy
o (2011-present) Professor, Kyungpook National University, College of Pharmacy
o (2005-2011) Assistant, Associate Professor Kyungpook National University, College of Natural Sciences,
o (2003-2004) Postdoctoral Researcher, Korea Institute of Science & Technology (KIST), Seoul, Korea
o (2001-2003) BK21 Professor, Seoul National University, College of Medicine,
o (1996-2001) Research fellow, Harvard Medical School, Children’s Hospital Boston
o (2015~2016) Post-Doc, Pusan National University

Hypoxia-induced angiogenesis and HIF-1 stability in tumor progression and metastasis, Role of endothelial cells in tissue microenvironment in disease development, Silencing of tumor suppressors in hypoxia-induced tumor progression

o Byun JK, Lee SH, Moon EJ, Park MH, Jang H, Weitzel DH, Kim HH, Basnet N, Kwon DY, Lee CT, Stephenson TN, Jeong JH, Patel BA, Park SJ, Chi JT, Dewhirst MW, Hong J, Lee YM. Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity. Br J Cancer. 2023 Apr. 128(8): 1491-1502.
o Sora Cha , Hyoung-Geun Kim, Hyeonha Jang, Jihoon Lee, Tang Chao, Nam-In Baek, Im-Sook Song, You Mie Lee. Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium. Phytomedicine 2023 Jan. 108:154513
o Jang B, Song HK, Hwang J, Lee S, Park E, Oh A, Hwang ES, Sung JY, Kim YN, Park K, Lee YM*, Oh ES*. Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment. Matrix Biol. 2022 Mar;107:40-58. doi: 10.1016/j.matbio.2022.02.001. PMID: 35139425
o Lee SH, Hyeon DY, Yoon SH, Jeong JH, Han SM, Jang JW, Nguyen MP, Chi XZ, An S, Hyun KG, Jung HJ, Song JJ, Bae SC, Kim WH, Hwang D, Lee YM*. RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis. Cell Death Differ. 2021 Apr; 28(4): 1251-1269. doi: 10.1038/s41418-020-00647-1. Online ahead of print.PMID: 33116296
o Choi YS, Jang H, Gupta B, Jeong JH, Ge Y, Yong CS, Kim JO, Bae JS, Song IS, Kim IS, Lee YM. Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities. J Hematol Oncol. 2020 Sep 14;13(1):123. doi: 10.1186/s13045-020-00952-9.PMID: 32928251
o Kwak SH, Stephenson TN, Lee HE, Ge Y, Lee H, Min SM, Kim JH, Kwon DY, Lee YM*, Hong J*. Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition. J Med Chem. 2020 Jul 9;63(13):6821-6833. doi: 10.1021/acs.jmedchem.0c00151. Epub 2020 Jun 24.PMID: 32579356
o Ge Y, Yoon SH, Jang H, Jeong JH, Lee YM. Decursin promotes HIF-1α proteasomal degradation and immune responses in hypoxic tumour microenvironment. Phytomedicine. 2020 Nov;78:153318. doi: 10.1016/j.phymed.2020.153318. Epub 2020 Sep 1.PMID: 32896707
o Jeong JH, Ojha U, Lee YM. Pathological angiogenesis and inflammation in tissues. Arch Pharm Res. 2021.01 44(1):1-15. doi: 10.1007/s12272-020-01287-2. Online ahead of print.PMID: 33230600
Park MH, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. Elife. 2019 Aug 20;8:e46012. doi: 10.7554/eLife.46012. PMID: 31429823; PMCID: PMC6726423.
o Kwon DY, Lee HE, et al. Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition. J Med Chem. 2015 Oct 8;58(19):7659-71. doi: 10.1021/acs.jmedchem.5b01220. Epub 2015 Sep 22. PMID: 26394152; PMID: PMC4765894.
o Lee SH, Bae SC, Kim KW, Lee YM. RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells. Oncogene 33 (11), 1458-1467 (2014)
66.
o YS Lee, JW Lee, JW Jang, XZ Chi, JH Kim, YH Li, MK Kim, DM Kim, BS Choi, EG Kim, JH Chung, OJ Lee, YM Lee, JW Suh, LS Chuang, Y Ito, SC Bae Runx3-inactivation is a crucial early event for lung adenocarcinoma development. Cancer Cell, 24, 603-616 (2013).Choi JH, Nguyen MP, Jung SY, Kwon SM, Jee JG, Bae JS, Lee S, Lee MY, Lee YM. Inhibitory effect of glyceollins on vasculogenesis through suppression of endothelial progenitor cell function Molecular Nutrition & Food Research 57(10):1762-1771 (2013).
o Lee SH, Lee J, Jung MH, Lee YM. Glyceollins, a novel class of soy phytoalexins, inhibit angiogenesis by blocking the VEGF and bFGF signaling pathway. Molecular Nutrition & Food Research 57, 225-234 (2013).
o Sun Hee Lee, XiangguoChe, Jae-Hwan Jeong, Je-Yong Choi, Young-Joo Lee, Yong-Hee Lee, Suk-Chul Bae, and You Mie Lee. Runx2 stabilizes hypoxia-inducible factor-1α through competition with pVHL and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J. Biol. Chem 287(18):14760-14771 (2012)
o Myung Hwan Jung, Sun Hee Lee, Eun-Mi Ahn, and You Mie Lee. Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR2 signaling pathway. Carcinogenesis 30(4) 655-661 (2009)
o SH Lee, J Kim, WH Kim, YM Lee. Hypoxic silencing of tumor suppressor RUNX3 by histon modification in gastric cancer cells. Oncogene 28(2) 184-194 (2009)
o Kheun Byeol Lee, Jong-Soo Lee, Jeen-Woo Park, Tae-Lin Huh, You Mie Lee. Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. Experimental and Molecular Medicine, 40(1), 118-129, (2008)
o Lee KB, Kim KR, Huh TL. Lee YM. Proton induces apoptosis of hypoxic tumor cells by the p53-dependent and p38/JNK MAPK signaling pathways. Int. J. Oncol 33(6) 1247-1256 (2008)
o Lee YM, Cope JJ, Ackermann GE, Goishi K, Armstrong EJ, Paw BH, Bischoff J. Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Developmetnal Dynamics. 235(1) 29-37 (2006).
o Noh EJ, Jang ER, Jeong G, Lee YM, Min CK, Lee JS. Methyl CpG-Binding Domain Protein 3 Mediates Cancer-Selective Cytotoxicity by Histone Deacetylase Inhibitors via Differential Transcriptional Reprogramming in Lung Cancer Cells. Cancer Res. 65(24):11400-10 (2005).
o Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem 277(1), 9-12 (2002).
o Kim YM, Kim YM, Lee YM, Kim HS, Kim JD, Choi Y, Kim KW, Lee SY, Kwon YG. TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and PLC in human endothelial cells. J Biol Chem 277(9), 6799-805 (2002).
o Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee, Jin Hyun Baek, Jae-Eun Jang, Eun-Joung Moon, Hae-Sun Kim, Seok-Ki Lee, Hae Young Chung, and Kyu-Won Kim. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nature Medicine, 7(4), 437-43 (2001).
o You Mie Lee, Chul-Ho Jung, Sun-Young Koo, Myung-Jin Son, Hyun Seok Song, Soo-Kyung Bae, James A Raleigh, Hae-Young Jung, Mi-Ae Yoo and Kyu-Won Kim. Determination of hypoxic region in developing mouse embryos: A possible signal to embryonic angiogenesis. Develomental Dynamics, 220(2), 175-186 (2001)