Abstract
In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against βsecretase (BACE1) with 9.2 × 10 -5M and Ki value of 5.5 × 10 -5 M. Loganin exhibited less inhibitory activity to β-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1471-1474 |
| Number of pages | 4 |
| Journal | Natural Product Research |
| Volume | 27 |
| Issue number | 16 |
| DOIs | |
| State | Published - 2013 |
Keywords
- β-amyloid peptide
- β-secretase
- Alzheimer's disease
- Corni fructus
- Loganin
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