β-secretase (BACE1) inhibitory property of loganin isolated from Corni fructus

Kumju Youn; Woo Sik Jeong; Mira Jun

doi:10.1080/14786419.2012.718774

β-secretase (BACE1) inhibitory property of loganin isolated from Corni fructus

Kumju Youn, Woo Sik Jeong, Mira Jun

School of Food Science & Biotechnology

Dong-A University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against βsecretase (BACE1) with 9.2 × 10 ^-5M and Ki value of 5.5 × 10 ^-5 M. Loganin exhibited less inhibitory activity to β-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.

Original language	English
Pages (from-to)	1471-1474
Number of pages	4
Journal	Natural Product Research
Volume	27
Issue number	16
DOIs	https://doi.org/10.1080/14786419.2012.718774
State	Published - 2013

Keywords

β-amyloid peptide
β-secretase
Alzheimer's disease
Corni fructus
Loganin

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10.1080/14786419.2012.718774

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title = "β-secretase (BACE1) inhibitory property of loganin isolated from Corni fructus",

abstract = "In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against βsecretase (BACE1) with 9.2 × 10 -5M and Ki value of 5.5 × 10 -5 M. Loganin exhibited less inhibitory activity to β-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.",

keywords = "β-amyloid peptide, β-secretase, Alzheimer's disease, Corni fructus, Loganin",

author = "Kumju Youn and Jeong, \{Woo Sik\} and Mira Jun",

year = "2013",

doi = "10.1080/14786419.2012.718774",

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journal = "Natural Product Research",

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T1 - β-secretase (BACE1) inhibitory property of loganin isolated from Corni fructus

AU - Youn, Kumju

AU - Jeong, Woo Sik

AU - Jun, Mira

PY - 2013

Y1 - 2013

N2 - In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against βsecretase (BACE1) with 9.2 × 10 -5M and Ki value of 5.5 × 10 -5 M. Loganin exhibited less inhibitory activity to β-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.

AB - In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against βsecretase (BACE1) with 9.2 × 10 -5M and Ki value of 5.5 × 10 -5 M. Loganin exhibited less inhibitory activity to β-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.

KW - β-amyloid peptide

KW - β-secretase

KW - Alzheimer's disease

KW - Corni fructus

KW - Loganin

UR - https://www.scopus.com/pages/publications/84884229500

U2 - 10.1080/14786419.2012.718774

DO - 10.1080/14786419.2012.718774

M3 - Article

C2 - 22931211

AN - SCOPUS:84884229500

SN - 1478-6419

VL - 27

SP - 1471

EP - 1474

JO - Natural Product Research

JF - Natural Product Research

IS - 16

ER -

β-secretase (BACE1) inhibitory property of loganin isolated from Corni fructus

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Keywords

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