Abstract
Platelets play fundamental roles in hemostasis and thrombosis, and antiplatelet drugs effectively reduce thrombosis in patients with cardiovascular disease. However, various side effects have been reported, and although various antiplatelet drugs have been developed, mortality rates of cardiovascular diseases have not decreased. Therefore, new antiplatelet drugs with fewer side effects are urgently required. This study examined whether Tenebrio molitor extract inhibits platelet aggregation by regulating integrin αIIb/β3 and its associated signaling molecules. Tenebrio molitor extract inhibited αIIb/β3 activation by regulating vasodilator-stimulated phosphoprotein, phosphatidylinositol-3 kinase, Akt, and glycogen synthase kinase-3α/β. In summary, Tenebrio molitor extract exhibited strong antiplatelet effects and appears to be a potential therapeutic for preventing platelet-related thrombosis and cardiovascular disease.
| Translated title of the contribution | Inhibitory Effects of Tenebrio molitor Extract on Platelet Function and Thrombus Formation through Glycoprotein IIb/IIIa Suppression |
|---|---|
| Original language | Korean |
| Pages (from-to) | 24-30 |
| Number of pages | 7 |
| Journal | Journal of the Korean Society of Food Science and Nutrition |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2024 |
Keywords
- clot retraction
- fibronectin adhesion
- integrin αIIb/β3
- Tenebrio molitor
