Abstract
Isoorientin is a component ofbeen in medicinal plants. In this research, isoorientin was purified from Oplismenus undulatifolius and its ability to inhibit inflammation was investigated. Cell toxicity was not expressed at concentrations below 100 μg/ mL of isoorientin. iNOS-derived NO and COX-2-derived PTGES2 m-RNA expression inhibition activities by the extracts which were found to be determined by the isoorientin concentration. Also, the cytokine and chemokine inhibitory activities of TNF-α, IL-6, IL-1β and MCP-1 via a pre-inflammatory mechanism were decreased upon an addition of isoorientin. The results here show that isoorientin decreases inflammatory reactions in Raw 264.7 cells with LPS via the regulation of iNOS, COX-2, NO, PTGES2, and cytokines and chemokines, demonstrating that isoorientin from Oplismenus undulatifolius is an excellent functional resource with strong anti-inflammatory activity.
| Translated title of the contribution | Inhibition of p-65, COX-2, iNOS and Cytokine Inflammation Signaling Pathway by Purified isoorientin from Oplismenus undulatifolius on Pro-inflammatory Responses |
|---|---|
| Original language | Korean |
| Pages (from-to) | 769-780 |
| Number of pages | 12 |
| Journal | Horticultural Science and Technology |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2025 |
Keywords
- anti-inflammation
- cell viability
- plant source
- protein expression
- purified compound
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