크리핑 로즈마리(Rosmarinus officinalis prostratus)의 미용 활성 분석 및 예측

In this study, antioxidant, whitening, anti-wrinkle, and pore contraction properties were analyzed. The total phenolic contents of creeping rosemary (CR) under optimal extraction conditions in water extract (CRWE) and 70% ethanol extract (CREE) were 23.03 mg/g and 29.56 mg/g, respectively. DPPH and ABTS free radical scavenging activities of CRWE and CREE were approximately 83% and 99% at 100 μg/g, respectively. Moreover, the antioxidant protection factor of CRWE and CREE was 1.83 and 1.84 at 100 μg/g, respectively. CRWE was shown 100% hyaluronidase inhibition, 45.38% collagenase inhibition as anti-inflammation and wrinkle improvement properties. CREE exerted higher inhibitory activities about tyrosinase, collagenase, elastase, hyaluronidase, astringent effect on 38.86%, 29.59%, 38.87%, 59.59%, and 14.14%, respectively. Using the support vector regression statistics model to predict optimal conditions for biological activity, the optimal inhibitory concentrations for DPPH, ABTS, and antioxidant protection factor were predicted to be 100 μg and TBARs was predicted to be 70 μg. The optimal inhibitory concentrations of tyrosinase and elastase were predicted to be 400 μg and 200 μg, respectively. For collagenase and hyaluronidase inhibition, the optimal concentrations were predicted to be 320 μg and 200 μg for CRWE and 400 μg of both enzymes for CREE, respectively. In addition, the optimal concentration for the astringent effect was predicted to be 400 μg. These results indicated the antioxidant, whitening, pore-tightening, and anti-wrinkle properties of CR extracts, which have potential use as ingredients for cosmetics.