Abstract
Background: 2′-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. Materials and Methods: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. Results: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G2/M-phase and increased the number of cells in the sub-G1 (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells. Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass. Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model. Conclusion: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
Original language | English |
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Pages (from-to) | 489-494 |
Number of pages | 6 |
Journal | Anticancer Research |
Volume | 30 |
Issue number | 2 |
State | Published - Feb 2010 |
Keywords
- 2′-Hydroxycinnamaldehyde
- Apoptosis
- Cell cycle
- Oral cancer
- Tumor model