2′-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model

Soo A. Kim, Young Kwan Sung, Byoung Mog Kwon, Jung Hoon Yoon, Haeahm Lee, Sang Gun Ahn, Su Hyung Hong

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: 2′-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. Materials and Methods: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. Results: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G2/M-phase and increased the number of cells in the sub-G1 (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells. Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass. Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model. Conclusion: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.

Original languageEnglish
Pages (from-to)489-494
Number of pages6
JournalAnticancer Research
Volume30
Issue number2
StatePublished - Feb 2010

Keywords

  • 2′-Hydroxycinnamaldehyde
  • Apoptosis
  • Cell cycle
  • Oral cancer
  • Tumor model

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