2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway

Young Min Han; Dae Seop Shin; Yu Jin Lee; Ismail Ahmed Ismail; Su Hyung Hong; Dong Cho Han; Byoung Mog Kwon

doi:10.1016/j.bmcl.2010.11.114

2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway

Young Min Han, Dae Seop Shin, Yu Jin Lee, Ismail Ahmed Ismail, Su Hyung Hong, Dong Cho Han, Byoung Mog Kwon

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI ₅₀ value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI ₅₀ values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.

Original language	English
Pages (from-to)	747-751
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.114
State	Published - 15 Jan 2011

Keywords

Apoptosis
Curcuminoid
Hydroxycinnamaldehyde
Reactive oxygen species

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10.1016/j.bmcl.2010.11.114

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title = "2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway",

abstract = "2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI 50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI 50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.",

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author = "Han, {Young Min} and Shin, {Dae Seop} and Lee, {Yu Jin} and Ismail, {Ismail Ahmed} and Hong, {Su Hyung} and Han, {Dong Cho} and Kwon, {Byoung Mog}",

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T1 - 2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway

AU - Han, Young Min

AU - Shin, Dae Seop

AU - Lee, Yu Jin

AU - Ismail, Ismail Ahmed

AU - Hong, Su Hyung

AU - Han, Dong Cho

AU - Kwon, Byoung Mog

PY - 2011/1/15

Y1 - 2011/1/15

N2 - 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI 50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI 50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.

AB - 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI 50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI 50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.

KW - Apoptosis

KW - Curcuminoid

KW - Hydroxycinnamaldehyde

KW - Reactive oxygen species

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2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway

Abstract

Keywords

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