2,2-Diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glucosidase inhibitor

Dong Sun Lee, Nam Soon Kim, Sang Han Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Glycosidases play a pivotal role in processing of various glycoproteins and glycolipids. It is well known that glycosidases are also involved in a variety of degenerative metabolic disorders such as cancer and AIDS. In order to develop potent α-glucosidase inhibitors, we first screened 2,2-diphenyl-1-picrylhydrazyl hydrate as a candidate. 2,2-Diphenyl-1-picrylhydrazyl hydrate was found to inhibit α- and β-glucosidases as well as α- and β-mannosidases. It was also shown to be a non-competitive inhibitor of yeast α-glucosidase with a Ki value of 1.1×10-6 M. Taken together, we anticipate that 2,2-diphenyl-1-picrylhydrazyl hydrate may be a potent inhibitor for some incurable metabolic disorders including AIDS.

Original languageEnglish
Pages (from-to)727-728
Number of pages2
JournalBiological and Pharmaceutical Bulletin
Volume24
Issue number6
DOIs
StatePublished - 2001

Keywords

  • α-glucosidase inhibitor
  • 2,2-Diphenyl-1-picrylhydrazyl hydrate
  • Enzyme kinetics
  • Non-competitive inhibition

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