2,3,7,8-Tetrachlorodibenzo-p-dioxin can alter the sex ratio of embryos with decreased viability of Y spermatozoa in mice

Young Ah You, Elsayed A. Mohamed, Md Saidur Rahman, Woo Sung Kwon, Won Hee Song, Buom Yong Ryu, Myung Geol Pang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a reproductive and developmental toxicant that can alter the sex ratio of offspring (proportion of male offspring). We hypothesized that the alteration of sex ratio is associated with sex chromosome ratio of live spermatozoa affected by exposure to TCDD. After exposure to TCDD we analyzed simultaneously sperm sex chromosome constitution and viability, and evaluated sperm sex chromosome ratio association with embryo sex ratio in mice. Short-term exposure to TCDD affects the decreased sperm motility and viability, and the increased acrosome reaction. Interestingly, Y spermatozoa survived shorter than X spermatozoa at high concentrations of TCDD. Moreover, the decreased sex ratio of embryos was associated with the short lifespan of Y spermatozoa. Our results suggest that TCDD may affect the fertility of Y spermatozoa more than X spermatozoa. Further studies are needed to compare the difference of fertilizing capability between X and Y spermatozoa by the effect of TCDD.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalReproductive Toxicology
Volume77
DOIs
StatePublished - Apr 2018

Keywords

  • Dioxin
  • Endocrine disruptor
  • Lifespan
  • Sex ratio
  • Spermatozoa

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