TY - JOUR
T1 - 2,4-Diaryl benzofuro[3,2-b]pyridine derivatives
T2 - Design, synthesis, and evaluation of topoisomerase inhibitory activity and cytotoxicity
AU - Thapa, Pritam
AU - Jahng, Yurngdong
AU - Park, Pil Hoon
AU - Jee, Jun Goo
AU - Kwon, Youngjoo
AU - Lee, Eung Seok
PY - 2013/10/20
Y1 - 2013/10/20
N2 - Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3- furyl, 2- or 3-thienyl, and 2-pyridyl were substituted at 2- or 4- position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2- or 4- position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 μM.
AB - Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3- furyl, 2- or 3-thienyl, and 2-pyridyl were substituted at 2- or 4- position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2- or 4- position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 μM.
KW - 2,4-Diaryl benzofuro[3,2-b]pyridine
KW - Cytotoxicity
KW - Topoisomerase I and II inhibition
UR - http://www.scopus.com/inward/record.url?scp=84889242801&partnerID=8YFLogxK
U2 - 10.5012/bkcs.2013.34.10.3073
DO - 10.5012/bkcs.2013.34.10.3073
M3 - Article
AN - SCOPUS:84889242801
SN - 0253-2964
VL - 34
SP - 3073
EP - 3082
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
IS - 10
ER -
