(3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin

Dong H. Kim; Jae Jeong Ryoo

doi:10.1016/0960-894X(95)00216-G

(3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin

Dong H. Kim, Jae Jeong Ryoo

Department of Chemical Science Education

Pohang University of Science and Technology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

(3R,4S)-3-Benzyl-4-(bromomethyl)oxetan-2-one is a novel type of fast acting alternate substrate inhibitor for α-chymotrypsin. The hydroxyl group that is generated during the turnover process appears to be responsible for the high stability of the acyl enzyme intermediate.

Original language	English
Pages (from-to)	1287-1292
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/0960-894X(95)00216-G
State	Published - 22 Jun 1995

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title = "(3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin",

abstract = "(3R,4S)-3-Benzyl-4-(bromomethyl)oxetan-2-one is a novel type of fast acting alternate substrate inhibitor for α-chymotrypsin. The hydroxyl group that is generated during the turnover process appears to be responsible for the high stability of the acyl enzyme intermediate.",

author = "Kim, {Dong H.} and Ryoo, {Jae Jeong}",

year = "1995",

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doi = "10.1016/0960-894X(95)00216-G",

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T1 - (3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin

AU - Kim, Dong H.

AU - Ryoo, Jae Jeong

PY - 1995/6/22

Y1 - 1995/6/22

N2 - (3R,4S)-3-Benzyl-4-(bromomethyl)oxetan-2-one is a novel type of fast acting alternate substrate inhibitor for α-chymotrypsin. The hydroxyl group that is generated during the turnover process appears to be responsible for the high stability of the acyl enzyme intermediate.

AB - (3R,4S)-3-Benzyl-4-(bromomethyl)oxetan-2-one is a novel type of fast acting alternate substrate inhibitor for α-chymotrypsin. The hydroxyl group that is generated during the turnover process appears to be responsible for the high stability of the acyl enzyme intermediate.

UR - http://www.scopus.com/inward/record.url?scp=0029046842&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(95)00216-G

DO - 10.1016/0960-894X(95)00216-G

M3 - Article

AN - SCOPUS:0029046842

SN - 0960-894X

VL - 5

SP - 1287

EP - 1292

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

(3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin

Abstract

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