4-hexylresorcinol inhibits class i histone deacetylases in human umbilical cord endothelial cells

Jwa Young Kim; Hae Yong Kweon; Dae Won Kim; Je Yong Choi; Seong Gon Kim

doi:10.3390/app11083486

4-hexylresorcinol inhibits class i histone deacetylases in human umbilical cord endothelial cells

Jwa Young Kim, Hae Yong Kweon, Dae Won Kim, Je Yong Choi, Seong Gon Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor for class I HDACs using the HDAC inhibitor (HDACi) Trichostatin-A as a positive control. The 4HR was administered 1–100 µM to human umbilical endothelial cells (HUVECs) and the HDAC expression and activity were examined. The 4HR decreased the expression level of HDAC1, 3, 4, and 5 in a time and dose-dependent manner. The 4HR also increased acetylated lysine and decreased HDAC activity significantly (p < 0.05). Collectively, 4HR was a new class I HDAC inhibitor that reduced the expression and activity of HDAC in HUVECs.

Original language	English
Article number	3486
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/app11083486
State	Published - 2 Apr 2021

Keywords

4-hexylresorcinol
ATP
Histone deacetylase
Mitochondria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "4-hexylresorcinol inhibits class i histone deacetylases in human umbilical cord endothelial cells",

abstract = "Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor for class I HDACs using the HDAC inhibitor (HDACi) Trichostatin-A as a positive control. The 4HR was administered 1–100 µM to human umbilical endothelial cells (HUVECs) and the HDAC expression and activity were examined. The 4HR decreased the expression level of HDAC1, 3, 4, and 5 in a time and dose-dependent manner. The 4HR also increased acetylated lysine and decreased HDAC activity significantly (p < 0.05). Collectively, 4HR was a new class I HDAC inhibitor that reduced the expression and activity of HDAC in HUVECs.",

keywords = "4-hexylresorcinol, ATP, Histone deacetylase, Mitochondria",

author = "Kim, {Jwa Young} and Kweon, {Hae Yong} and Kim, {Dae Won} and Choi, {Je Yong} and Kim, {Seong Gon}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/app11083486",

language = "English",

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T1 - 4-hexylresorcinol inhibits class i histone deacetylases in human umbilical cord endothelial cells

AU - Kim, Jwa Young

AU - Kweon, Hae Yong

AU - Kim, Dae Won

AU - Choi, Je Yong

AU - Kim, Seong Gon

PY - 2021/4/2

Y1 - 2021/4/2

N2 - Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor for class I HDACs using the HDAC inhibitor (HDACi) Trichostatin-A as a positive control. The 4HR was administered 1–100 µM to human umbilical endothelial cells (HUVECs) and the HDAC expression and activity were examined. The 4HR decreased the expression level of HDAC1, 3, 4, and 5 in a time and dose-dependent manner. The 4HR also increased acetylated lysine and decreased HDAC activity significantly (p < 0.05). Collectively, 4HR was a new class I HDAC inhibitor that reduced the expression and activity of HDAC in HUVECs.

AB - Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor for class I HDACs using the HDAC inhibitor (HDACi) Trichostatin-A as a positive control. The 4HR was administered 1–100 µM to human umbilical endothelial cells (HUVECs) and the HDAC expression and activity were examined. The 4HR decreased the expression level of HDAC1, 3, 4, and 5 in a time and dose-dependent manner. The 4HR also increased acetylated lysine and decreased HDAC activity significantly (p < 0.05). Collectively, 4HR was a new class I HDAC inhibitor that reduced the expression and activity of HDAC in HUVECs.

KW - 4-hexylresorcinol

KW - ATP

KW - Histone deacetylase

KW - Mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85104104308&partnerID=8YFLogxK

U2 - 10.3390/app11083486

DO - 10.3390/app11083486

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SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 8

M1 - 3486

ER -

4-hexylresorcinol inhibits class i histone deacetylases in human umbilical cord endothelial cells

Abstract

Keywords

UN SDGs

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