4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells

Seong Gon Kim; Jae Hwan Jeong; Young Wook Park; Ji Young Song; A. N.Sook Kim; J. E.Yong Choi; Weon Sik Chae

doi:10.3892/or.2011.1218

4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells

Seong Gon Kim, Jae Hwan Jeong, Young Wook Park, Ji Young Song, A. N.Sook Kim, J. E.Yong Choi, Weon Sik Chae

Department of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Resistance to chemotherapy is very important in the prognosis of tumors. Transglutaminase-2 (TG-2) mediated chemotherapy resistance has been widely reported. The objective of this study was to demonstrate the effect of 4-hexylresorcinol (4-HR) on TG-2 activity in nasopharyngeal squamous cell carcinoma cells (KB cells). Treatment with a mixture of 4-HR and cisplatin significantly decreased KB cell viability compared to treatment by cisplatin alone at 10 μg/ml (p<0.001). 4-HR inhibited TG-2 activity compared to cisplatin alone at 5, 10 and 20 μg/ml (p=0.001, 0.001 and 0.003, respectively). Nuclear translocation of TG-2 was also inhibited by 4-HR treatment 4-HR treatment also increased the fluorescence life-time of DAPI significantly compared to the untreated control or the cisplatin treated group (p<0.001). In conclusion, 4-HR inhibited TG-2 activity and showed a synergistic effect on tumor cell growth inhibition with cisplatin.

Original language	English
Pages (from-to)	1597-1602
Number of pages	6
Journal	Oncology Reports
Volume	25
Issue number	6
DOIs	https://doi.org/10.3892/or.2011.1218
State	Published - Jun 2011

Keywords

4-Hexylresorcinol
Cisplatin
Squamous cell carcinoma
Transglutaminase-2

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10.3892/or.2011.1218

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title = "4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells",

abstract = "Resistance to chemotherapy is very important in the prognosis of tumors. Transglutaminase-2 (TG-2) mediated chemotherapy resistance has been widely reported. The objective of this study was to demonstrate the effect of 4-hexylresorcinol (4-HR) on TG-2 activity in nasopharyngeal squamous cell carcinoma cells (KB cells). Treatment with a mixture of 4-HR and cisplatin significantly decreased KB cell viability compared to treatment by cisplatin alone at 10 μg/ml (p<0.001). 4-HR inhibited TG-2 activity compared to cisplatin alone at 5, 10 and 20 μg/ml (p=0.001, 0.001 and 0.003, respectively). Nuclear translocation of TG-2 was also inhibited by 4-HR treatment 4-HR treatment also increased the fluorescence life-time of DAPI significantly compared to the untreated control or the cisplatin treated group (p<0.001). In conclusion, 4-HR inhibited TG-2 activity and showed a synergistic effect on tumor cell growth inhibition with cisplatin.",

keywords = "4-Hexylresorcinol, Cisplatin, Squamous cell carcinoma, Transglutaminase-2",

author = "Kim, {Seong Gon} and Jeong, {Jae Hwan} and Park, {Young Wook} and Song, {Ji Young} and Kim, {A. N.Sook} and Choi, {J. E.Yong} and Chae, {Weon Sik}",

year = "2011",

month = jun,

doi = "10.3892/or.2011.1218",

language = "English",

volume = "25",

pages = "1597--1602",

journal = "Oncology Reports",

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T1 - 4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells

AU - Kim, Seong Gon

AU - Jeong, Jae Hwan

AU - Park, Young Wook

AU - Song, Ji Young

AU - Kim, A. N.Sook

AU - Choi, J. E.Yong

AU - Chae, Weon Sik

PY - 2011/6

Y1 - 2011/6

N2 - Resistance to chemotherapy is very important in the prognosis of tumors. Transglutaminase-2 (TG-2) mediated chemotherapy resistance has been widely reported. The objective of this study was to demonstrate the effect of 4-hexylresorcinol (4-HR) on TG-2 activity in nasopharyngeal squamous cell carcinoma cells (KB cells). Treatment with a mixture of 4-HR and cisplatin significantly decreased KB cell viability compared to treatment by cisplatin alone at 10 μg/ml (p<0.001). 4-HR inhibited TG-2 activity compared to cisplatin alone at 5, 10 and 20 μg/ml (p=0.001, 0.001 and 0.003, respectively). Nuclear translocation of TG-2 was also inhibited by 4-HR treatment 4-HR treatment also increased the fluorescence life-time of DAPI significantly compared to the untreated control or the cisplatin treated group (p<0.001). In conclusion, 4-HR inhibited TG-2 activity and showed a synergistic effect on tumor cell growth inhibition with cisplatin.

AB - Resistance to chemotherapy is very important in the prognosis of tumors. Transglutaminase-2 (TG-2) mediated chemotherapy resistance has been widely reported. The objective of this study was to demonstrate the effect of 4-hexylresorcinol (4-HR) on TG-2 activity in nasopharyngeal squamous cell carcinoma cells (KB cells). Treatment with a mixture of 4-HR and cisplatin significantly decreased KB cell viability compared to treatment by cisplatin alone at 10 μg/ml (p<0.001). 4-HR inhibited TG-2 activity compared to cisplatin alone at 5, 10 and 20 μg/ml (p=0.001, 0.001 and 0.003, respectively). Nuclear translocation of TG-2 was also inhibited by 4-HR treatment 4-HR treatment also increased the fluorescence life-time of DAPI significantly compared to the untreated control or the cisplatin treated group (p<0.001). In conclusion, 4-HR inhibited TG-2 activity and showed a synergistic effect on tumor cell growth inhibition with cisplatin.

KW - 4-Hexylresorcinol

KW - Cisplatin

KW - Squamous cell carcinoma

KW - Transglutaminase-2

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SN - 1021-335X

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JO - Oncology Reports

JF - Oncology Reports

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ER -

4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells

Abstract

Keywords

UN SDGs

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