4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain

Jeoung Hee Ha; Dong Ung Lee; Jae Tae Lee; Jin Sook Kim; Chul Soon Yong; Jung Ae Kim; Jung Sang Ha; Keun Huh

doi:10.1016/S0378-8741(00)00313-5

4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain

Jeoung Hee Ha, Dong Ung Lee, Jae Tae Lee, Jin Sook Kim, Chul Soon Yong, Jung Ae Kim, Jung Sang Ha, Keun Huh

Department of Medicine

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4- hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	73
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-8741(00)00313-5
State	Published - 2000

Keywords

4-Hydroxybenzaldehyde
Anticonvulsant
GABAergic neuromodulation
Gatrodia elata B1.

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10.1016/S0378-8741(00)00313-5

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title = "4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain",

abstract = "Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4- hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "4-Hydroxybenzaldehyde, Anticonvulsant, GABAergic neuromodulation, Gatrodia elata B1.",

author = "Ha, {Jeoung Hee} and Lee, {Dong Ung} and Lee, {Jae Tae} and Kim, {Jin Sook} and Yong, {Chul Soon} and Kim, {Jung Ae} and Ha, {Jung Sang} and Keun Huh",

year = "2000",

doi = "10.1016/S0378-8741(00)00313-5",

language = "English",

volume = "73",

pages = "329--333",

journal = "Journal of Ethnopharmacology",

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T1 - 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain

AU - Ha, Jeoung Hee

AU - Lee, Dong Ung

AU - Lee, Jae Tae

AU - Kim, Jin Sook

AU - Yong, Chul Soon

AU - Kim, Jung Ae

AU - Ha, Jung Sang

AU - Huh, Keun

PY - 2000

Y1 - 2000

N2 - Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4- hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1. (C) 2000 Elsevier Science Ireland Ltd.

AB - Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4- hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1. (C) 2000 Elsevier Science Ireland Ltd.

KW - 4-Hydroxybenzaldehyde

KW - Anticonvulsant

KW - GABAergic neuromodulation

KW - Gatrodia elata B1.

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U2 - 10.1016/S0378-8741(00)00313-5

DO - 10.1016/S0378-8741(00)00313-5

M3 - Article

C2 - 11025174

AN - SCOPUS:0033802170

SN - 0378-8741

VL - 73

SP - 329

EP - 333

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 1-2

ER -

4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain

Abstract

Keywords

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