4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

Inho Yang; Jisoo Yoon; Dayoung Kim; Dongyup Hahn; Sang Jip Nam; William Fenical

doi:10.1016/j.tetlet.2017.03.088

4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

Inho Yang, Jisoo Yoon, Dayoung Kim, Dongyup Hahn, Sang Jip Nam, William Fenical

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.

Original language	English
Pages (from-to)	2322-2324
Number of pages	3
Journal	Tetrahedron Letters
Volume	58
Issue number	24
DOIs	https://doi.org/10.1016/j.tetlet.2017.03.088
State	Published - 2017

Keywords

14-Membered macrolide
Kromycin derivative
Marine-derived Streptomyces sp.
Pikromycin aglycone

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10.1016/j.tetlet.2017.03.088

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@article{613b7dcbbf5a4d2a96540af86221c390,

title = "4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.",

abstract = "HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.",

keywords = "14-Membered macrolide, Kromycin derivative, Marine-derived Streptomyces sp., Pikromycin aglycone",

author = "Inho Yang and Jisoo Yoon and Dayoung Kim and Dongyup Hahn and Nam, \{Sang Jip\} and William Fenical",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

doi = "10.1016/j.tetlet.2017.03.088",

language = "English",

volume = "58",

pages = "2322--2324",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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}

TY - JOUR

T1 - 4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

AU - Yang, Inho

AU - Yoon, Jisoo

AU - Kim, Dayoung

AU - Hahn, Dongyup

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2017

Y1 - 2017

N2 - HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.

AB - HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.

KW - 14-Membered macrolide

KW - Kromycin derivative

KW - Marine-derived Streptomyces sp.

KW - Pikromycin aglycone

UR - https://www.scopus.com/pages/publications/85019203813

U2 - 10.1016/j.tetlet.2017.03.088

DO - 10.1016/j.tetlet.2017.03.088

M3 - Article

AN - SCOPUS:85019203813

SN - 0040-4039

VL - 58

SP - 2322

EP - 2324

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 24

ER -

4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

Abstract

Keywords

UN SDGs

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