Abstract
In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.
| Original language | English |
|---|---|
| Pages (from-to) | 1067-1070 |
| Number of pages | 4 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 14 |
| Issue number | 5 |
| State | Published - Oct 2004 |
Keywords
- 7-oxostaurosporine
- Candida albicans
- Morphological transition