7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

Eui Il Hwang; Bong Sik Yun; Sang Han Lee; Soo Kie Kim; Se Jin Lim; Sung Uk Kim

7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

Eui Il Hwang
, Bong Sik Yun
, Sang Han Lee
, Soo Kie Kim
, Se Jin Lim
, Sung Uk Kim

KT and G Central Research Institute
Korea Research Institute of Bioscience and Biotechnology
Yonsei University Wonju College of Medicine
Dongduk Women's University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.

Original language	English
Pages (from-to)	1067-1070
Number of pages	4
Journal	Journal of Microbiology and Biotechnology
Volume	14
Issue number	5
State	Published - Oct 2004

Keywords

7-oxostaurosporine
Candida albicans
Morphological transition

Cite this

@article{e2d3cb2d5e01433190a6cbdca2403a81,

title = "7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans",

abstract = "In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.",

keywords = "7-oxostaurosporine, Candida albicans, Morphological transition",

author = "Hwang, \{Eui Il\} and Yun, \{Bong Sik\} and Lee, \{Sang Han\} and Kim, \{Soo Kie\} and Lim, \{Se Jin\} and Kim, \{Sung Uk\}",

year = "2004",

month = oct,

language = "English",

volume = "14",

pages = "1067--1070",

journal = "Journal of Microbiology and Biotechnology",

issn = "1017-7825",

publisher = "Korean Society for Microbiolog and Biotechnology",

number = "5",

}

TY - JOUR

T1 - 7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

AU - Hwang, Eui Il

AU - Yun, Bong Sik

AU - Lee, Sang Han

AU - Kim, Soo Kie

AU - Lim, Se Jin

AU - Kim, Sung Uk

PY - 2004/10

Y1 - 2004/10

N2 - In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.

AB - In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.

KW - 7-oxostaurosporine

KW - Candida albicans

KW - Morphological transition

UR - https://www.scopus.com/pages/publications/8644239546

M3 - Article

AN - SCOPUS:8644239546

SN - 1017-7825

VL - 14

SP - 1067

EP - 1070

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 5

ER -

7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

Abstract

Keywords

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