A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Eugene Lih; Wooram Park; Ki Wan Park; So Young Chun; Hyuncheol Kim; Yoon Ki Joung; Tae Gyun Kwon; Jeffrey A. Hubbell; Dong Keun Han

doi:10.1021/acscentsci.8b00812

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Eugene Lih
, Wooram Park
, Ki Wan Park
, So Young Chun
, Hyuncheol Kim
, Yoon Ki Joung
, Tae Gyun Kwon
, Jeffrey A. Hubbell
, Dong Keun Han

Department of Medicine

Korea Institute of Science and Technology
CHA University
Sogang University
Kyungpook National University
The University of Chicago

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) ₂ ), and decellularized renal extracellular matrix (ECM). The Mg(OH) ₂ inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) ₂ scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) ₂ scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

Original language	English
Pages (from-to)	458-467
Number of pages	10
Journal	ACS Central Science
Volume	5
Issue number	3
DOIs	https://doi.org/10.1021/acscentsci.8b00812
State	Published - 27 Mar 2019

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SDG 3 Good Health and Well-being

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title = "A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration",

abstract = " Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.",

author = "Eugene Lih and Wooram Park and Park, \{Ki Wan\} and Chun, \{So Young\} and Hyuncheol Kim and Joung, \{Yoon Ki\} and Kwon, \{Tae Gyun\} and Hubbell, \{Jeffrey A.\} and Han, \{Dong Keun\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acscentsci.8b00812",

language = "English",

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T1 - A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

AU - Lih, Eugene

AU - Park, Wooram

AU - Park, Ki Wan

AU - Chun, So Young

AU - Kim, Hyuncheol

AU - Joung, Yoon Ki

AU - Kwon, Tae Gyun

AU - Hubbell, Jeffrey A.

AU - Han, Dong Keun

PY - 2019/3/27

Y1 - 2019/3/27

N2 - Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

AB - Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

UR - https://www.scopus.com/pages/publications/85060724097

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DO - 10.1021/acscentsci.8b00812

M3 - Article

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SN - 2374-7943

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EP - 467

JO - ACS Central Science

JF - ACS Central Science

IS - 3

ER -

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

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