A case of feline extramedullary plasma cell tumor with T cell infiltration

Jung Hyun Kim; Jiwoong Yoon; Sol Ji Choi; Woo Jin Song; Youngmin Yun; Myung Chul Kim

doi:10.14405/kjvr.20240040

A case of feline extramedullary plasma cell tumor with T cell infiltration

Jung Hyun Kim, Jiwoong Yoon, Sol Ji Choi, Woo Jin Song, Youngmin Yun, Myung Chul Kim

Department of Veterinary Medicine

Jeju National University

Research output: Contribution to journal › Article › peer-review

Abstract

A 7-year-old castrated male Persian cat presented with a cutaneous mass and an increase in serum amyloid A concentration. Fine needle aspirates of the mass indicated lymphoma, which was also the top differential diagnosis on histopathologic examinations. Immunohistochemically, neoplastic cells tested negative for anti-CD3, PAX5, CD20, and c-Kit, but positive for MUM1, CD79α, and CD138, suggesting extramedullary plasmacytoma. There were tumor-infiltrating non-neoplastic CD3⁺ T and PAX5⁺ B cells. Practitioners should be aware of feline plasmacytoma characterized by lymphoma-like cytologic and histologic features. The present study is valuable in providing the first clinical evidence that proves the immunogenicity of feline plasmacytoma.

Original language	English
Article number	e25
Journal	Korean Journal of Veterinary Research
Volume	64
Issue number	3
DOIs	https://doi.org/10.14405/kjvr.20240040
State	Published - Sep 2024

Keywords

cats
plasmacytoma
synthetic immunogens
tumor infiltrating lymphocyte

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10.14405/kjvr.20240040

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title = "A case of feline extramedullary plasma cell tumor with T cell infiltration",

abstract = "A 7-year-old castrated male Persian cat presented with a cutaneous mass and an increase in serum amyloid A concentration. Fine needle aspirates of the mass indicated lymphoma, which was also the top differential diagnosis on histopathologic examinations. Immunohistochemically, neoplastic cells tested negative for anti-CD3, PAX5, CD20, and c-Kit, but positive for MUM1, CD79α, and CD138, suggesting extramedullary plasmacytoma. There were tumor-infiltrating non-neoplastic CD3+ T and PAX5+ B cells. Practitioners should be aware of feline plasmacytoma characterized by lymphoma-like cytologic and histologic features. The present study is valuable in providing the first clinical evidence that proves the immunogenicity of feline plasmacytoma.",

keywords = "cats, plasmacytoma, synthetic immunogens, tumor infiltrating lymphocyte",

author = "Kim, \{Jung Hyun\} and Jiwoong Yoon and Choi, \{Sol Ji\} and Song, \{Woo Jin\} and Youngmin Yun and Kim, \{Myung Chul\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Korean Society of Veterinary Science.",

year = "2024",

month = sep,

doi = "10.14405/kjvr.20240040",

language = "English",

volume = "64",

journal = "Korean Journal of Veterinary Research",

issn = "2466-1384",

publisher = "Korean Society of Veterinary Science",

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T1 - A case of feline extramedullary plasma cell tumor with T cell infiltration

AU - Kim, Jung Hyun

AU - Yoon, Jiwoong

AU - Choi, Sol Ji

AU - Song, Woo Jin

AU - Yun, Youngmin

AU - Kim, Myung Chul

PY - 2024/9

Y1 - 2024/9

N2 - A 7-year-old castrated male Persian cat presented with a cutaneous mass and an increase in serum amyloid A concentration. Fine needle aspirates of the mass indicated lymphoma, which was also the top differential diagnosis on histopathologic examinations. Immunohistochemically, neoplastic cells tested negative for anti-CD3, PAX5, CD20, and c-Kit, but positive for MUM1, CD79α, and CD138, suggesting extramedullary plasmacytoma. There were tumor-infiltrating non-neoplastic CD3+ T and PAX5+ B cells. Practitioners should be aware of feline plasmacytoma characterized by lymphoma-like cytologic and histologic features. The present study is valuable in providing the first clinical evidence that proves the immunogenicity of feline plasmacytoma.

AB - A 7-year-old castrated male Persian cat presented with a cutaneous mass and an increase in serum amyloid A concentration. Fine needle aspirates of the mass indicated lymphoma, which was also the top differential diagnosis on histopathologic examinations. Immunohistochemically, neoplastic cells tested negative for anti-CD3, PAX5, CD20, and c-Kit, but positive for MUM1, CD79α, and CD138, suggesting extramedullary plasmacytoma. There were tumor-infiltrating non-neoplastic CD3+ T and PAX5+ B cells. Practitioners should be aware of feline plasmacytoma characterized by lymphoma-like cytologic and histologic features. The present study is valuable in providing the first clinical evidence that proves the immunogenicity of feline plasmacytoma.

KW - cats

KW - plasmacytoma

KW - synthetic immunogens

KW - tumor infiltrating lymphocyte

UR - https://www.scopus.com/pages/publications/85205481315

U2 - 10.14405/kjvr.20240040

DO - 10.14405/kjvr.20240040

M3 - Article

AN - SCOPUS:85205481315

SN - 2466-1384

VL - 64

JO - Korean Journal of Veterinary Research

JF - Korean Journal of Veterinary Research

IS - 3

M1 - e25

ER -

A case of feline extramedullary plasma cell tumor with T cell infiltration

Abstract

Keywords

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