A case of granular cell tumors

Granular cell tumors are uncommon benign tumors occurring most commonly on the tongue, skin and subcutaneous tissue. They are most often seen as a solitary nodule in adults. Multiple lesions are very rare, particularly in children. We report a case of multiple granular cell tumors in a 13-year-old boy on his left arm which was presented as firm, flesh-colored, match-head to pea-sized, tender nodules for 6 months. Histologically, the tumors are nonencapsulated nodules, composed of large, polyhedral cells with an abundant eosinophilic granular cytoplasm. By immunohistochemistry, the granular cells are strongly positive for S-100 protein.