A Case of Hepatic Immunoglobulin G4-Related Disease Presenting as an Inflammatory Pseudotumor and Sclerosing Cholangitis

Se Young Jang; Young Seok Han; Sang Yub Lee; Ja Ryung Han; Young Oh Kweon; Won Young Tak; Soo Young Park; Yu Rim Lee; Hun Kyu Ryeom; Jung Guen Cha; Jihoon Hong; Yoo Na Kang

doi:10.3390/diagnostics12061497

A Case of Hepatic Immunoglobulin G4-Related Disease Presenting as an Inflammatory Pseudotumor and Sclerosing Cholangitis

Se Young Jang, Young Seok Han, Sang Yub Lee, Ja Ryung Han, Young Oh Kweon, Won Young Tak, Soo Young Park, Yu Rim Lee, Hun Kyu Ryeom, Jung Guen Cha, Jihoon Hong, Yoo Na Kang

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Recently, some inflammatory pseudotumor cases proved to be a form of Immunoglobulin G4-related disease (IgG4-RD). This novel clinical entity, recognized as a fibroinflammatory condition, is characterized by lymphoplasmacytic infiltration with a predominance of IgG4-positive plasma cells, storiform fibrosis, and often elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. We recommend that for diagnosing IgG4-RD accurately, it is important to obtain adequate tissue samples and follow-up the lesion in clinical practice.

Original language	English
Article number	1497
Journal	Diagnostics
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/diagnostics12061497
State	Published - Jun 2022

Keywords

biopsy
cholangitis
immunoglobulin G4-related disease
immunohistochemistry
liver
sclerosing
surgery

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10.3390/diagnostics12061497

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title = "A Case of Hepatic Immunoglobulin G4-Related Disease Presenting as an Inflammatory Pseudotumor and Sclerosing Cholangitis",

abstract = "An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Recently, some inflammatory pseudotumor cases proved to be a form of Immunoglobulin G4-related disease (IgG4-RD). This novel clinical entity, recognized as a fibroinflammatory condition, is characterized by lymphoplasmacytic infiltration with a predominance of IgG4-positive plasma cells, storiform fibrosis, and often elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. We recommend that for diagnosing IgG4-RD accurately, it is important to obtain adequate tissue samples and follow-up the lesion in clinical practice.",

keywords = "biopsy, cholangitis, immunoglobulin G4-related disease, immunohistochemistry, liver, sclerosing, surgery",

author = "Jang, {Se Young} and Han, {Young Seok} and Lee, {Sang Yub} and Han, {Ja Ryung} and Kweon, {Young Oh} and Tak, {Won Young} and Park, {Soo Young} and Lee, {Yu Rim} and Ryeom, {Hun Kyu} and Cha, {Jung Guen} and Jihoon Hong and Kang, {Yoo Na}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

doi = "10.3390/diagnostics12061497",

language = "English",

volume = "12",

journal = "Diagnostics",

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AU - Jang, Se Young

AU - Han, Young Seok

AU - Lee, Sang Yub

AU - Han, Ja Ryung

AU - Kweon, Young Oh

AU - Tak, Won Young

AU - Park, Soo Young

AU - Lee, Yu Rim

AU - Ryeom, Hun Kyu

AU - Cha, Jung Guen

AU - Hong, Jihoon

AU - Kang, Yoo Na

PY - 2022/6

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N2 - An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Recently, some inflammatory pseudotumor cases proved to be a form of Immunoglobulin G4-related disease (IgG4-RD). This novel clinical entity, recognized as a fibroinflammatory condition, is characterized by lymphoplasmacytic infiltration with a predominance of IgG4-positive plasma cells, storiform fibrosis, and often elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. We recommend that for diagnosing IgG4-RD accurately, it is important to obtain adequate tissue samples and follow-up the lesion in clinical practice.

AB - An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Recently, some inflammatory pseudotumor cases proved to be a form of Immunoglobulin G4-related disease (IgG4-RD). This novel clinical entity, recognized as a fibroinflammatory condition, is characterized by lymphoplasmacytic infiltration with a predominance of IgG4-positive plasma cells, storiform fibrosis, and often elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. We recommend that for diagnosing IgG4-RD accurately, it is important to obtain adequate tissue samples and follow-up the lesion in clinical practice.

KW - biopsy

KW - cholangitis

KW - immunoglobulin G4-related disease

KW - immunohistochemistry

KW - liver

KW - sclerosing

KW - surgery

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DO - 10.3390/diagnostics12061497

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SN - 2075-4418

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JO - Diagnostics

JF - Diagnostics

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ER -

A Case of Hepatic Immunoglobulin G4-Related Disease Presenting as an Inflammatory Pseudotumor and Sclerosing Cholangitis

Abstract

Keywords

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