A Case of Improvement of Refractory Acrodermatitis Continua of Hallopeau with Guselkumab

Jin Ho Kim, Dae Lyong Ha, Yong Hyun Jang

Research output: Contribution to journalArticlepeer-review

Abstract

Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis that causes periungual sterile pustules, paronychia, onychodystrophy, osteolysis, and atrophic skin. This condition is known for being resistant to conventional anti-psoriatic treatments. Therefore, biologies have been explored as potential management options for ACH. A 48-year-old male presented with erythematous swelling, pustular eruptions, desquamation, and nail dystrophy on his left third fingertip for a year. Despite various anti-psoriatic treatments, including 308 nm excimer laser, oral cyclosporine, acitretin, and methotrexate, the symptoms persisted. After 9 years of experiencing this condition, the patient was started on guselkumab (an interleukin-23 inhibitor), and showed significant improvement after eight injections. The patient was in good health without any adverse effects. This case report highlights the potential effectiveness of guselkumab in the treatment of refractory ACH.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalKorean Journal of Dermatology
Volume62
Issue number1
StatePublished - Jan 2024

Keywords

  • Acrodermatitis continua of Hallopeau, Guselkumab

Fingerprint

Dive into the research topics of 'A Case of Improvement of Refractory Acrodermatitis Continua of Hallopeau with Guselkumab'. Together they form a unique fingerprint.

Cite this