A case of pulmonary thromboembolism possibly associated with the use of creatine supplements

Drug administration should be considered a risk factor for venous thromboembolism (VTE) in younger healthy patients. We present a case of new-onset pulmonary embolism (PE), possibly associated with excessive creatine supplement intake. A 24-year-old non-smoker male presented to the emergency department with sudden-onset dyspnoea and chest discomfort. Computed tomography pulmonary angiography and venography confirmed PE in the left and right pulmonary artery branches and a thrombus in the left popliteal vein. The patient had no family history of VTE, and other causes of thrombophilia were unlikely. He reported a recent increase in the intensity of his workouts and the dose of his creatine supplements in preparation for a bodybuilding competition. The creatine supplements likely promoted dehydration during intense workouts and profuse sweating. He received anticoagulation therapy, and the creatine supplements were discontinued. Creatine supplements should be used cautiously when there is a higher risk of becoming dehydrated.