A case of transient central diabetes insipidus after aorto-coronary bypass operation

Chung Hoon Yu, Jang Hee Cho, Hee Yeon Jung, Jeong Hoon Lim, Mi Kyung Jin, Owen Kwon, Kyung Deuk Hong, Ji Young Choi, Se Hee Yoon, Chan Duck Kim, Yong Lim Kim, Gun Jik Kim, Sun Hee Park

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Diabetes insipidus (DI) is characterized by excessive urination and thirst. This disease results from inadequate output of antidiuretic hormone (ADH) from the pituitary gland or the absence of the normal response to ADH in the kidney. We present a case of transient central DI in a patient who underwent a cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG). A 44-yr-old male underwent a CABG operation. An hour after the operation, the patient developed polyuria and was diagnosed with central DI. The patient responded to desmopressin and completely recovered five days after surgery. It is probable that transient cerebral ischemia resulted in the dysfunction of osmotic receptors in the hypothalamus or hypothalamus-pituitary axis during CPB. It is also possible that cardiac standstill altered the left atrial non-osmotic receptor function and suppressed ADH release. Therefore, we suggest that central DI is a possible cause of polyuria after CPB.

Original languageEnglish
Pages (from-to)1109-1113
Number of pages5
JournalJournal of Korean Medical Science
Volume27
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Aorto-coronary bypass
  • Central diabetes insipidus
  • Polyuria

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