Abstract
Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by 1 μg/ml of lipopolysaccharide (LPS) in murine RAW264.7 cells. In order to compare the anti-inflammatory effects of surfactin isoforms, we examined the inhibition of LPS-induced NO production and the pro-inflammatory cytokine expression level. Surfactin C inhibited the LPS-induced NO production in murine macrophage RAW264.7 cells the most. In addition, surfactin C was superior to other surfactin's subtypes regarding inhibiting the expression of inducible nitric oxide synthase (iNOS) and monocyte chemoattractant protein 1 (MCP-1). Finally, the anti-inflammatory activity of surfactin C is the most potent, compared with surfactin A, B, and D.
| Original language | English |
|---|---|
| Pages (from-to) | 1656-1659 |
| Number of pages | 4 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 16 |
| Issue number | 10 |
| State | Published - Oct 2006 |
Keywords
- Anti-inflammatory activity
- Inducible nitric oxide synthase
- Nitric oxide
- Pro-inflammatory cytokines
- Surfactin A, B, C, D