A copper(II)-catalyzed protocol for modified Friedländer quinoline synthesis

Chan Sik Cho, Wen Xiu Ren, Sang Chul Shim

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2-Aminobenzyl alcohol reacts with an array of ketones in dioxane at 100 °C in the presence of a catalytic amount of CuCl2 along with KOH under O2 atmosphere to afford the corresponding quinolines in good yields. 2-Aminobenzyl alcohol is also oxidatively coupled and cyclized with various aldehydes by step-by-step procedure, an initial treatment of 2-aminobenzyl alcohol in the presence of CuCl2 and KOH in dioxane under O2 atmosphere and subsequent addition of aldehyde to the mixture followed by stirring under argon atmosphere, to give 3-substituted quinolines in moderate to good yields.

Original languageEnglish
Pages (from-to)6781-6785
Number of pages5
JournalTetrahedron Letters
Issue number38
StatePublished - 18 Sep 2006


  • 2-Aminobenzyl alcohol
  • Aldehydes
  • Copper catalyst
  • Ketones
  • Quinolines


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