A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee; Junyoung Seo; Soyoung Kwak; Eun Ji Park; Dong Hee Na; Soyoun Kim; You Mie Lee; In San Kim; Jong Sup Bae

doi:10.1002/adma.201503093

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee, Junyoung Seo, Soyoung Kwak, Eun Ji Park, Dong Hee Na, Soyoun Kim, You Mie Lee, In San Kim, Jong Sup Bae

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

Original language	English
Pages (from-to)	6637-6643
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	42
DOIs	https://doi.org/10.1002/adma.201503093
State	Published - 1 Nov 2015

Keywords

PC-gla
TRAP
ferritin
nanoparticles
sepsis

Access to Document

10.1002/adma.201503093

Cite this

@article{d4d45172a15d455e809b110e6afed4b6,

title = "A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment",

abstract = "New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.",

keywords = "PC-gla, TRAP, ferritin, nanoparticles, sepsis",

author = "Wonhwa Lee and Junyoung Seo and Soyoung Kwak and Park, {Eun Ji} and Na, {Dong Hee} and Soyoun Kim and Lee, {You Mie} and Kim, {In San} and Bae, {Jong Sup}",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = nov,

day = "1",

doi = "10.1002/adma.201503093",

language = "English",

volume = "27",

pages = "6637--6643",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "42",

}

TY - JOUR

T1 - A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

AU - Lee, Wonhwa

AU - Seo, Junyoung

AU - Kwak, Soyoung

AU - Park, Eun Ji

AU - Na, Dong Hee

AU - Kim, Soyoun

AU - Lee, You Mie

AU - Kim, In San

AU - Bae, Jong Sup

PY - 2015/11/1

Y1 - 2015/11/1

N2 - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

AB - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

KW - PC-gla

KW - TRAP

KW - ferritin

KW - nanoparticles

KW - sepsis

UR - http://www.scopus.com/inward/record.url?scp=84946763409&partnerID=8YFLogxK

U2 - 10.1002/adma.201503093

DO - 10.1002/adma.201503093

M3 - Article

C2 - 26414883

AN - SCOPUS:84946763409

SN - 0935-9648

VL - 27

SP - 6637

EP - 6643

JO - Advanced Materials

JF - Advanced Materials

IS - 42

ER -

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this