A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent

Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Jung Lee; Badrul Alam Bony; Woo Choul Heo; Jae Jun Lee; Seonguk Jin; Jong Su Baeck; Yongmin Chang; Tae Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

doi:10.1021/am200437r

A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent

Krishna Kattel
, Ja Young Park
, Wenlong Xu
, Han Gyeol Kim
, Eun Jung Lee
, Badrul Alam Bony
, Woo Choul Heo
, Jae Jun Lee
, Seonguk Jin
, Jong Su Baeck
, Yongmin Chang
, Tae Jeong Kim
, Ji Eun Bae
, Kwon Seok Chae
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln ₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy₂O₃ nanoparticle because it showed the highest r₂ relaxivity among studied nanoparticles. Its performance as a T₂ MRI contrast agent was for the first time proved in vivo through its 3 T T₂ MR images of a mouse, showing that it can be further exploited for the rational design of a new T ₂ MRI contrast agent at high MR fields.

Original language	English
Pages (from-to)	3325-3334
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/am200437r
State	Published - 28 Sep 2011

Keywords

LnO
MRI contrast agent
one-pot synthesis
ultrasmall nanoparticle

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10.1021/am200437r

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Kattel, K., Park, J. Y., Xu, W., Kim, H. G., Lee, E. J., Bony, B. A., Heo, W. C., Lee, J. J., Jin, S., Baeck, J. S., Chang, Y., Kim, T. J., Bae, J. E., Chae, K. S., & Lee, G. H. (2011). A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent. ACS Applied Materials and Interfaces, 3(9), 3325-3334. https://doi.org/10.1021/am200437r

@article{e0e1c7a5a89d488d99dd2461e56679be,

title = "A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent",

abstract = "A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln 2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy2O3 nanoparticle because it showed the highest r2 relaxivity among studied nanoparticles. Its performance as a T2 MRI contrast agent was for the first time proved in vivo through its 3 T T2 MR images of a mouse, showing that it can be further exploited for the rational design of a new T 2 MRI contrast agent at high MR fields.",

keywords = "LnO, MRI contrast agent, one-pot synthesis, ultrasmall nanoparticle",

author = "Krishna Kattel and Park, \{Ja Young\} and Wenlong Xu and Kim, \{Han Gyeol\} and Lee, \{Eun Jung\} and Bony, \{Badrul Alam\} and Heo, \{Woo Choul\} and Lee, \{Jae Jun\} and Seonguk Jin and Baeck, \{Jong Su\} and Yongmin Chang and Kim, \{Tae Jeong\} and Bae, \{Ji Eun\} and Chae, \{Kwon Seok\} and Lee, \{Gang Ho\}",

year = "2011",

month = sep,

day = "28",

doi = "10.1021/am200437r",

language = "English",

volume = "3",

pages = "3325--3334",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "9",

}

Kattel, K, Park, JY, Xu, W, Kim, HG, Lee, EJ, Bony, BA, Heo, WC, Lee, JJ, Jin, S, Baeck, JS, Chang, Y, Kim, TJ, Bae, JE, Chae, KS & Lee, GH 2011, 'A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent', ACS Applied Materials and Interfaces, vol. 3, no. 9, pp. 3325-3334. https://doi.org/10.1021/am200437r

A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent. / Kattel, Krishna; Park, Ja Young; Xu, Wenlong et al.
In: ACS Applied Materials and Interfaces, Vol. 3, No. 9, 28.09.2011, p. 3325-3334.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent

AU - Kattel, Krishna

AU - Park, Ja Young

AU - Xu, Wenlong

AU - Kim, Han Gyeol

AU - Lee, Eun Jung

AU - Bony, Badrul Alam

AU - Heo, Woo Choul

AU - Lee, Jae Jun

AU - Jin, Seonguk

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Kim, Tae Jeong

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Lee, Gang Ho

PY - 2011/9/28

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N2 - A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln 2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy2O3 nanoparticle because it showed the highest r2 relaxivity among studied nanoparticles. Its performance as a T2 MRI contrast agent was for the first time proved in vivo through its 3 T T2 MR images of a mouse, showing that it can be further exploited for the rational design of a new T 2 MRI contrast agent at high MR fields.

AB - A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln 2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy2O3 nanoparticle because it showed the highest r2 relaxivity among studied nanoparticles. Its performance as a T2 MRI contrast agent was for the first time proved in vivo through its 3 T T2 MR images of a mouse, showing that it can be further exploited for the rational design of a new T 2 MRI contrast agent at high MR fields.

KW - LnO

KW - MRI contrast agent

KW - one-pot synthesis

KW - ultrasmall nanoparticle

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AN - SCOPUS:84862833205

SN - 1944-8244

VL - 3

SP - 3325

EP - 3334

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 9

ER -

A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent

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