A highly efficient new T1 MRI contrast agent with r2/r1 ≈ 1.0: Mixed Cu(II)/Gd(III) oxide nanoparticle

Badrul Alam Bony; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

doi:10.1002/bkcs.10230

A highly efficient new T₁ MRI contrast agent with r₂/r₁ ≈ 1.0: Mixed Cu(II)/Gd(III) oxide nanoparticle

Badrul Alam Bony, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An ideal T₁ MRI contrast agent should have a large r₁ value and r₂/r₁ ratio, which is close to 1. In this study, a new approach to accomplish this is presented using the mixed Cu(II)/Gd(III) oxide nanoparticle. The D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle showed r₁ = 13.78 mM^-1 s^-1 and r₂ = 14.48 mM^-1 s^-1 (r₂/r₁ = 1.05). This result is due to reduced magnetization of mixed nanoparticle resulting from mixing of nearly nonmagnetic Cu(II) into the nanoparticle. This result shows that the D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle is a potential T₁ MRI contrast agent.

Original language	English
Pages (from-to)	1203-1208
Number of pages	6
Journal	Bulletin of the Korean Chemical Society
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/bkcs.10230
State	Published - 1 Apr 2015

Keywords

Mixed Cu(II)/Gd(III) oxide nanoparticle
T MRI contrast agent
Water proton relaxivity
r/r ratio

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10.1002/bkcs.10230

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title = "A highly efficient new T1 MRI contrast agent with r2/r1 ≈ 1.0: Mixed Cu(II)/Gd(III) oxide nanoparticle",

abstract = "An ideal T1 MRI contrast agent should have a large r1 value and r2/r1 ratio, which is close to 1. In this study, a new approach to accomplish this is presented using the mixed Cu(II)/Gd(III) oxide nanoparticle. The D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle showed r1 = 13.78 mM-1 s-1 and r2 = 14.48 mM-1 s-1 (r2/r1 = 1.05). This result is due to reduced magnetization of mixed nanoparticle resulting from mixing of nearly nonmagnetic Cu(II) into the nanoparticle. This result shows that the D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle is a potential T1 MRI contrast agent.",

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AU - Bony, Badrul Alam

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Lee, Gang Ho

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AB - An ideal T1 MRI contrast agent should have a large r1 value and r2/r1 ratio, which is close to 1. In this study, a new approach to accomplish this is presented using the mixed Cu(II)/Gd(III) oxide nanoparticle. The D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle showed r1 = 13.78 mM-1 s-1 and r2 = 14.48 mM-1 s-1 (r2/r1 = 1.05). This result is due to reduced magnetization of mixed nanoparticle resulting from mixing of nearly nonmagnetic Cu(II) into the nanoparticle. This result shows that the D-glucuronic acid-coated Cu(II)/Gd(III) oxide nanoparticle is a potential T1 MRI contrast agent.

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A highly efficient new T₁ MRI contrast agent with r₂/r₁ ≈ 1.0: Mixed Cu(II)/Gd(III) oxide nanoparticle

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Keywords

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