A Mechanistic Evaluation for the Resolution of Enantiomers of ±-Arylpropionic Acid Derivatives on π-Basic Chiral Stationary Phases

Myung Ho Hyun; Sung Min Cho; Jae Jeong Ryoo; Mi Son Kim

doi:10.1080/10826079408013354

A Mechanistic Evaluation for the Resolution of Enantiomers of ±-Arylpropionic Acid Derivatives on π-Basic Chiral Stationary Phases

Myung Ho Hyun, Sung Min Cho, Jae Jeong Ryoo, Mi Son Kim

Department of Chemical Science Education

Pusan National University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A chiral recognition mechanism involving face to edge π-πinteraction for the separation of the two enantiomers of the 3,5-dinitroanilide derivatives of nonsteroidal anti-inflammatory drugs(NSAIDs) on chiral stationary phase(CSP) 1 has been proposed. The inverse chromatographic resolution trends observed in resolving the two enantiomers of the 3,5-dinitroanilide derivatives of a-phenylalkanoic acids and a-(p-alkylphenyl)propionic acids on CSP 1 and 2 may support the postulated chiral recognition mechanism.

Original language	English
Pages (from-to)	317-328
Number of pages	12
Journal	Journal of Liquid Chromatography
Volume	17
Issue number	2
DOIs	https://doi.org/10.1080/10826079408013354
State	Published - 1 Jan 1994

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abstract = "A chiral recognition mechanism involving face to edge π-πinteraction for the separation of the two enantiomers of the 3,5-dinitroanilide derivatives of nonsteroidal anti-inflammatory drugs(NSAIDs) on chiral stationary phase(CSP) 1 has been proposed. The inverse chromatographic resolution trends observed in resolving the two enantiomers of the 3,5-dinitroanilide derivatives of a-phenylalkanoic acids and a-(p-alkylphenyl)propionic acids on CSP 1 and 2 may support the postulated chiral recognition mechanism.",

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AU - Ryoo, Jae Jeong

AU - Kim, Mi Son

PY - 1994/1/1

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N2 - A chiral recognition mechanism involving face to edge π-πinteraction for the separation of the two enantiomers of the 3,5-dinitroanilide derivatives of nonsteroidal anti-inflammatory drugs(NSAIDs) on chiral stationary phase(CSP) 1 has been proposed. The inverse chromatographic resolution trends observed in resolving the two enantiomers of the 3,5-dinitroanilide derivatives of a-phenylalkanoic acids and a-(p-alkylphenyl)propionic acids on CSP 1 and 2 may support the postulated chiral recognition mechanism.

AB - A chiral recognition mechanism involving face to edge π-πinteraction for the separation of the two enantiomers of the 3,5-dinitroanilide derivatives of nonsteroidal anti-inflammatory drugs(NSAIDs) on chiral stationary phase(CSP) 1 has been proposed. The inverse chromatographic resolution trends observed in resolving the two enantiomers of the 3,5-dinitroanilide derivatives of a-phenylalkanoic acids and a-(p-alkylphenyl)propionic acids on CSP 1 and 2 may support the postulated chiral recognition mechanism.

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A Mechanistic Evaluation for the Resolution of Enantiomers of ±-Arylpropionic Acid Derivatives on π-Basic Chiral Stationary Phases

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