A new coumarin derivative and other compounds from Achillea alpina L. and their chemotaxonomic significance

Phytochemical investigation of the aerial parts of Achillea alpina L. (Asteraceae) led to the isolation and structural elucidation of one previously undescribed isofraxidin derivative and fifteen known compounds including five lignans (2–5, and 16), one coumarin glucoside (6), four flavonoids (7–10), three feruloylsucrose derivatives (11–13), one caffeoylquinic acid (14), and one polyacetylene (15). Their structures were determined by analyzing HR-ESI-MS and NMR data and comparing them with those in the references. To the best of our knowledge, this study was the first report of isolating compounds 1–4 and 13 from the family Asteraceae, compounds 1–4, 6, 13, and 15 from the genus Achillea, and compounds 1–6, 11–13, and 15 from A. alpina. Their chemotaxonomic significance was also discussed.