TY - JOUR
T1 - A new lignan glycoside from the fruits of Cornus kousa Burg.
AU - Lee, Dae Young
AU - Yoo, Ki Hyun
AU - Chung, In Sik
AU - Kim, Ji Young
AU - Chung, Dae Kyun
AU - Kim, Dae Keun
AU - Kim, Sung Hoon
AU - Baek, Nam In
PY - 2008/7
Y1 - 2008/7
N2 - A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, 1H-and 13C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC 50 = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.
AB - A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, 1H-and 13C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC 50 = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.
KW - (-)-Balanophonin
KW - (7'S, 8'R)-Dihydrodehydrodiconiferyl alcohol
KW - Cornus kousa
KW - Cornuskoside A
KW - Cytotoxicity
KW - Lignan glycoside
UR - http://www.scopus.com/inward/record.url?scp=49749094322&partnerID=8YFLogxK
U2 - 10.1007/s12272-001-1233-2
DO - 10.1007/s12272-001-1233-2
M3 - Article
C2 - 18704322
AN - SCOPUS:49749094322
SN - 0253-6269
VL - 31
SP - 830
EP - 833
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 7
ER -
