A new lignan glycoside from the fruits of Cornus kousa Burg.

Dae Young Lee; Ki Hyun Yoo; In Sik Chung; Ji Young Kim; Dae Kyun Chung; Dae Keun Kim; Sung Hoon Kim; Nam In Baek

doi:10.1007/s12272-001-1233-2

A new lignan glycoside from the fruits of Cornus kousa Burg.

Dae Young Lee
, Ki Hyun Yoo
, In Sik Chung
, Ji Young Kim
, Dae Kyun Chung
, Dae Keun Kim
, Sung Hoon Kim
, Nam In Baek

School of Life Science and Biotechnology

Kyung Hee University
Woosuk University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, ¹H-and ¹³C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC₅₀ = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC₅₀ = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC ₅₀ = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC₅₀ = 33.4 μM (2), 43.4 μM (3)] cell lines.

Original language	English
Pages (from-to)	830-833
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	31
Issue number	7
DOIs	https://doi.org/10.1007/s12272-001-1233-2
State	Published - Jul 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(-)-Balanophonin
(7'S, 8'R)-Dihydrodehydrodiconiferyl alcohol
Cornus kousa
Cornuskoside A
Cytotoxicity
Lignan glycoside

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10.1007/s12272-001-1233-2

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title = "A new lignan glycoside from the fruits of Cornus kousa Burg.",

abstract = "A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, 1H-and 13C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC 50 = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.",

keywords = "(-)-Balanophonin, (7'S, 8'R)-Dihydrodehydrodiconiferyl alcohol, Cornus kousa, Cornuskoside A, Cytotoxicity, Lignan glycoside",

author = "Lee, \{Dae Young\} and Yoo, \{Ki Hyun\} and Chung, \{In Sik\} and Kim, \{Ji Young\} and Chung, \{Dae Kyun\} and Kim, \{Dae Keun\} and Kim, \{Sung Hoon\} and Baek, \{Nam In\}",

year = "2008",

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doi = "10.1007/s12272-001-1233-2",

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journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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T1 - A new lignan glycoside from the fruits of Cornus kousa Burg.

AU - Lee, Dae Young

AU - Yoo, Ki Hyun

AU - Chung, In Sik

AU - Kim, Ji Young

AU - Chung, Dae Kyun

AU - Kim, Dae Keun

AU - Kim, Sung Hoon

AU - Baek, Nam In

PY - 2008/7

Y1 - 2008/7

N2 - A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, 1H-and 13C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC 50 = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.

AB - A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, 1H-and 13C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC 50 = 31.3 μM (2), 32.3 μM (3)], and SK-OV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.

KW - (-)-Balanophonin

KW - (7'S, 8'R)-Dihydrodehydrodiconiferyl alcohol

KW - Cornus kousa

KW - Cornuskoside A

KW - Cytotoxicity

KW - Lignan glycoside

UR - https://www.scopus.com/pages/publications/49749094322

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DO - 10.1007/s12272-001-1233-2

M3 - Article

C2 - 18704322

AN - SCOPUS:49749094322

SN - 0253-6269

VL - 31

SP - 830

EP - 833

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 7

ER -

A new lignan glycoside from the fruits of Cornus kousa Burg.

Abstract

UN SDGs

Keywords

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