TY - JOUR
T1 - A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity
AU - Luyen, Bui Thi Thuy
AU - Tai, Bui Huu
AU - Thao, Nguyen Phuong
AU - Yang, Seo Young
AU - Cuong, Nguyen Manh
AU - Kwon, Young In
AU - Jang, Hae Dong
AU - Kim, Young Ho
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Two new compounds, piperoside (1) and isoheptanol 2(S)-O-β-d- xylopyranosyl (1→6)-O-β-d-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-β-d-glucopyranosyl-4- allylbenzene (3), tachioside (4), benzyl-O-β-d-glucopyranoside (5), icariside F2 (6), dihydrovomifoliol-3′-O-β-d- glucopyranoside (7), isopropyl O-β-d-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-β-d-glucopyranoside (10), isoheptanol 2(S)-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Mosher's method, and comparisons with previous reports. All of the isolated compounds showed modest α-glucosidase inhibitory (4.60 ± 1.74% to 11.97 ± 3.30%) and antioxidant activities under the tested conditions.
AB - Two new compounds, piperoside (1) and isoheptanol 2(S)-O-β-d- xylopyranosyl (1→6)-O-β-d-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-β-d-glucopyranosyl-4- allylbenzene (3), tachioside (4), benzyl-O-β-d-glucopyranoside (5), icariside F2 (6), dihydrovomifoliol-3′-O-β-d- glucopyranoside (7), isopropyl O-β-d-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-β-d-glucopyranoside (10), isoheptanol 2(S)-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Mosher's method, and comparisons with previous reports. All of the isolated compounds showed modest α-glucosidase inhibitory (4.60 ± 1.74% to 11.97 ± 3.30%) and antioxidant activities under the tested conditions.
KW - Antioxidant
KW - Isoheptanol 2(S)-O-β-d-xylopyranosyl (1→6)-O-β-d-glucopyranoside
KW - Piper retrofractum
KW - Piperoside
KW - α-Glucosidase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=84906938433&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2014.07.057
DO - 10.1016/j.bmcl.2014.07.057
M3 - Article
C2 - 25127165
AN - SCOPUS:84906938433
SN - 0960-894X
VL - 24
SP - 4120
EP - 4124
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -