A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

Le Ba Vinh; Nguyen Thi Minh Nguyet; Seo Young Yang; Jang Hoon Kim; Le Thi Vien; Phan Thi Thanh Huong; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Chau Van Minh; Inkyu Hwang; Young Ho Kim

doi:10.1080/14786419.2017.1360885

A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

Le Ba Vinh, Nguyen Thi Minh Nguyet, Seo Young Yang, Jang Hoon Kim, Le Thi Vien, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh, Inkyu Hwang, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED₅₀ values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC₅₀ = 3.46 ± 0.01 μM).

Original language	English
Pages (from-to)	2001-2007
Number of pages	7
Journal	Natural Product Research
Volume	32
Issue number	17
DOIs	https://doi.org/10.1080/14786419.2017.1360885
State	Published - 2 Sep 2018

Keywords

Clerodendrum inerme
Verbenaceae
abietane diterpene
antioxidant
crolerodendrum B
cytotoxic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2017.1360885

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Ba Vinh, L., Thi Minh Nguyet, N., Young Yang, S., Hoon Kim, J., Thi Vien, L., Thi Thanh Huong, P., Van Thanh, N., Xuan Cuong, N., Hoai Nam, N., Van Minh, C., Hwang, I., & Ho Kim, Y. (2018). A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities. Natural Product Research, 32(17), 2001-2007. https://doi.org/10.1080/14786419.2017.1360885

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title = "A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities",

abstract = "Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED50 values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC50 = 3.46 ± 0.01 μM).",

keywords = "Clerodendrum inerme, Verbenaceae, abietane diterpene, antioxidant, crolerodendrum B, cytotoxic",

author = "{Ba Vinh}, Le and {Thi Minh Nguyet}, Nguyen and {Young Yang}, Seo and {Hoon Kim}, Jang and {Thi Vien}, Le and {Thi Thanh Huong}, Phan and {Van Thanh}, Nguyen and {Xuan Cuong}, Nguyen and {Hoai Nam}, Nguyen and {Van Minh}, Chau and Inkyu Hwang and {Ho Kim}, Young",

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Ba Vinh, L, Thi Minh Nguyet, N, Young Yang, S, Hoon Kim, J, Thi Vien, L, Thi Thanh Huong, P, Van Thanh, N, Xuan Cuong, N, Hoai Nam, N, Van Minh, C, Hwang, I & Ho Kim, Y 2018, 'A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities', Natural Product Research, vol. 32, no. 17, pp. 2001-2007. https://doi.org/10.1080/14786419.2017.1360885

TY - JOUR

T1 - A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

AU - Ba Vinh, Le

AU - Thi Minh Nguyet, Nguyen

AU - Young Yang, Seo

AU - Hoon Kim, Jang

AU - Thi Vien, Le

AU - Thi Thanh Huong, Phan

AU - Van Thanh, Nguyen

AU - Xuan Cuong, Nguyen

AU - Hoai Nam, Nguyen

AU - Van Minh, Chau

AU - Hwang, Inkyu

AU - Ho Kim, Young

PY - 2018/9/2

Y1 - 2018/9/2

N2 - Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED50 values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC50 = 3.46 ± 0.01 μM).

AB - Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED50 values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC50 = 3.46 ± 0.01 μM).

KW - Clerodendrum inerme

KW - Verbenaceae

KW - abietane diterpene

KW - antioxidant

KW - crolerodendrum B

KW - cytotoxic

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SN - 1478-6419

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JO - Natural Product Research

JF - Natural Product Research

IS - 17

ER -

A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

Abstract

Keywords

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