TY - JOUR
T1 - A new triterpenoid from Alisma orientale and their antibacterial effect
AU - Jin, Hong Guang
AU - Jin, Qinglong
AU - Ryun Kim, A.
AU - Choi, Hyemin
AU - Lee, Je Hyun
AU - Kim, Yeong Shik
AU - Lee, Dong Gun
AU - Woo, Eun Rhan
PY - 2012/11
Y1 - 2012/11
N2 - A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4β,12-dihydroxyguaian-6,10- diene (9), alisol C 23-acetate (10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1-15) were identified based on 1D and 2D NMR, including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 μg/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.
AB - A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4β,12-dihydroxyguaian-6,10- diene (9), alisol C 23-acetate (10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1-15) were identified based on 1D and 2D NMR, including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 μg/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.
KW - Alisma orientale
KW - Alismataceae
KW - Alisol Q 23-acetate
KW - Antibacterial effect
KW - Triterpenoid
UR - http://www.scopus.com/inward/record.url?scp=84874420843&partnerID=8YFLogxK
U2 - 10.1007/s12272-012-1108-5
DO - 10.1007/s12272-012-1108-5
M3 - Article
C2 - 23212633
AN - SCOPUS:84874420843
SN - 0253-6269
VL - 35
SP - 1919
EP - 1926
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 11
ER -