A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

Sabina Shrestha; Ji Hae Park; Dae Young Lee; Jin Gyeong Cho; En ji Cui; In Sik Chung; Byoung Mog Kwon; Moon Hee Cho; Tae Sook Jeong; Nam In Baek

doi:10.3839/jksabc.2011.049

A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

Sabina Shrestha, Ji Hae Park, Dae Young Lee, Jin Gyeong Cho, En ji Cui, In Sik Chung, Byoung Mog Kwon, Moon Hee Cho, Tae Sook Jeong, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC₅₀ value of 5 μM and low-density lipoprotein-oxidation with IC₅₀ value of 27.2 μM.

Original language	English
Pages (from-to)	308-311
Number of pages	4
Journal	Journal of Applied Biological Chemistry
Volume	54
Issue number	2
DOIs	https://doi.org/10.3839/jksabc.2011.049
State	Published - 2011

Keywords

2
6-dihydroxy-7-methoxy-3h-xanthen-3-one
Desmostatchya bipinnata
Low-density lipoprotein-oxidation
Signal transducer and activator of transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3839/jksabc.2011.049

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Shrestha, S., Park, J. H., Lee, D. Y., Cho, J. G., Cui, E. J., Chung, I. S., Kwon, B. M., Cho, M. H., Jeong, T. S., & Baek, N. I. (2011). A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation. Journal of Applied Biological Chemistry, 54(2), 308-311. https://doi.org/10.3839/jksabc.2011.049

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title = "A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation",

abstract = "A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC50 value of 5 μM and low-density lipoprotein-oxidation with IC50 value of 27.2 μM.",

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year = "2011",

doi = "10.3839/jksabc.2011.049",

language = "English",

volume = "54",

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journal = "Journal of Applied Biological Chemistry",

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Shrestha, S, Park, JH, Lee, DY, Cho, JG, Cui, EJ, Chung, IS, Kwon, BM, Cho, MH, Jeong, TS & Baek, NI 2011, 'A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation', Journal of Applied Biological Chemistry, vol. 54, no. 2, pp. 308-311. https://doi.org/10.3839/jksabc.2011.049

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T1 - A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

AU - Shrestha, Sabina

AU - Park, Ji Hae

AU - Lee, Dae Young

AU - Cho, Jin Gyeong

AU - Cui, En ji

AU - Chung, In Sik

AU - Kwon, Byoung Mog

AU - Cho, Moon Hee

AU - Jeong, Tae Sook

AU - Baek, Nam In

PY - 2011

Y1 - 2011

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AB - A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC50 value of 5 μM and low-density lipoprotein-oxidation with IC50 value of 27.2 μM.

KW - 2

KW - 6-dihydroxy-7-methoxy-3h-xanthen-3-one

KW - Desmostatchya bipinnata

KW - Low-density lipoprotein-oxidation

KW - Signal transducer and activator of transcription

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U2 - 10.3839/jksabc.2011.049

DO - 10.3839/jksabc.2011.049

M3 - Article

AN - SCOPUS:79956058755

SN - 1976-0442

VL - 54

SP - 308

EP - 311

JO - Journal of Applied Biological Chemistry

JF - Journal of Applied Biological Chemistry

IS - 2

ER -

A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

Abstract

Keywords

UN SDGs

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