A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages

Zhi Qiang Chang; Joong Su Lee; Mi Hyun Hwang; Joo Heon Hong; Hee Kyoung Jung; Sam Pin Lee; Seung Chun Park

doi:10.4142/jvs.2009.10.2.165

A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages

Zhi Qiang Chang, Joong Su Lee, Mi Hyun Hwang, Joo Heon Hong, Hee Kyoung Jung, Sam Pin Lee, Seung Chun Park

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effect of extracellular β-(1→3), (1→6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. β-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, β-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.

Original language	English
Pages (from-to)	165-167
Number of pages	3
Journal	Journal of Veterinary Science
Volume	10
Issue number	2
DOIs	https://doi.org/10.4142/jvs.2009.10.2.165
State	Published - Jun 2009

Keywords

β-Glucan
Macrophages
Nitric oxide
Paenibacillus polymyxa

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10.4142/jvs.2009.10.2.165

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title = "A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages",

abstract = "The effect of extracellular β-(1→3), (1→6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. β-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, β-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.",

keywords = "β-Glucan, Macrophages, Nitric oxide, Paenibacillus polymyxa",

author = "Chang, {Zhi Qiang} and Lee, {Joong Su} and Hwang, {Mi Hyun} and Hong, {Joo Heon} and Jung, {Hee Kyoung} and Lee, {Sam Pin} and Park, {Seung Chun}",

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AU - Lee, Joong Su

AU - Hwang, Mi Hyun

AU - Hong, Joo Heon

AU - Jung, Hee Kyoung

AU - Lee, Sam Pin

AU - Park, Seung Chun

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AB - The effect of extracellular β-(1→3), (1→6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. β-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, β-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.

KW - β-Glucan

KW - Macrophages

KW - Nitric oxide

KW - Paenibacillus polymyxa

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A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages

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