A Novel Paramagnetic Nanoparticle T2 Magnetic Resonance Imaging Contrast Agent With High Colloidal Stability: Polyacrylic Acid-Coated Ultrafine Dysprosium Oxide Nanoparticles

Shanti Marasini, Huan Yue, Son Long Ho, Hyunsil Cha, Ji Ae Park, Ki Hye Jung, Adibehalsadat Ghazanfari, Mohammad Yaseen Ahmad, Shuwen Liu, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Until now, there have been limited studies on T2 magnetic resonance imaging (MRI) contrast agents (CAs) using paramagnetic nanoparticles (NPs). In this study, ultrafine dysprosium oxide (Dy2O3) NPs were synthesized as a T2 MRI CA. To obtain high biocompatibility and colloidal stability in aqueous medium for in vivo applications, they were grafted with polyacrylic acid. They displayed paramagnetism with an appreciable magnetization value at 300 K and consequently, an appreciable transverse water proton spin relaxivity (r2) value which increased as the applied MR field increased. Their potential as a T2 MRI CA was proved by taking in vivo T2 MR images in mice.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalBulletin of the Korean Chemical Society
Volume41
Issue number8
DOIs
StatePublished - 1 Aug 2020

Keywords

  • High colloidal stability
  • Polyacrylic acid
  • T magnetic resonance imaging
  • Ultrafine DyO nanoparticle

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