A palladium-catalyzed route for α-alkylation of ketones by primary alcohols

Chan Sik Cho

doi:10.1016/j.molcata.2005.06.043

A palladium-catalyzed route for α-alkylation of ketones by primary alcohols

Chan Sik Cho

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Ketones react with primary alcohols in dioxane at 100 °C in the presence of a catalytic amount of Pd/C and KOH along with 1-decene as a sacrificial hydrogen acceptor to give the corresponding coupled ketones in moderate to good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of primary alcohols to aldehydes, cross aldol condensation, and regioselective reduction.

Original language	English
Pages (from-to)	55-60
Number of pages	6
Journal	Journal of Molecular Catalysis A: Chemical
Volume	240
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molcata.2005.06.043
State	Published - 3 Oct 2005

Keywords

α-Alkylation
Hydrogen acceptor
Ketones
Palladium catalyst
Primary alcohols

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10.1016/j.molcata.2005.06.043

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title = "A palladium-catalyzed route for α-alkylation of ketones by primary alcohols",

abstract = "Ketones react with primary alcohols in dioxane at 100 °C in the presence of a catalytic amount of Pd/C and KOH along with 1-decene as a sacrificial hydrogen acceptor to give the corresponding coupled ketones in moderate to good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of primary alcohols to aldehydes, cross aldol condensation, and regioselective reduction.",

keywords = "α-Alkylation, Hydrogen acceptor, Ketones, Palladium catalyst, Primary alcohols",

author = "Cho, \{Chan Sik\}",

year = "2005",

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T1 - A palladium-catalyzed route for α-alkylation of ketones by primary alcohols

AU - Cho, Chan Sik

PY - 2005/10/3

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N2 - Ketones react with primary alcohols in dioxane at 100 °C in the presence of a catalytic amount of Pd/C and KOH along with 1-decene as a sacrificial hydrogen acceptor to give the corresponding coupled ketones in moderate to good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of primary alcohols to aldehydes, cross aldol condensation, and regioselective reduction.

AB - Ketones react with primary alcohols in dioxane at 100 °C in the presence of a catalytic amount of Pd/C and KOH along with 1-decene as a sacrificial hydrogen acceptor to give the corresponding coupled ketones in moderate to good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of primary alcohols to aldehydes, cross aldol condensation, and regioselective reduction.

KW - α-Alkylation

KW - Hydrogen acceptor

KW - Ketones

KW - Palladium catalyst

KW - Primary alcohols

UR - https://www.scopus.com/pages/publications/24144462600

U2 - 10.1016/j.molcata.2005.06.043

DO - 10.1016/j.molcata.2005.06.043

M3 - Article

AN - SCOPUS:24144462600

SN - 1381-1169

VL - 240

SP - 55

EP - 60

JO - Journal of Molecular Catalysis A: Chemical

JF - Journal of Molecular Catalysis A: Chemical

IS - 1-2

ER -

A palladium-catalyzed route for α-alkylation of ketones by primary alcohols

Abstract

Keywords

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