Abstract
The preparation of polymer-supported proline-based diamine catalyst 12 for the kinetic resolution of racemic mixtures of secondary alcohols is described. Not only is the catalyst effective for the resolution of a host of different alcohols, it can also be recovered and reused several times without loss of either activity or selectivity. The catalyst has been used in conjunction with a polymer-supported sequestration strategy, giving rise to an essentially pure mixture of resolved products that can be separated using flash chromatography.
| Original language | English |
|---|---|
| Pages (from-to) | 868-873 |
| Number of pages | 6 |
| Journal | Journal of Organic Chemistry |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| State | Published - 9 Feb 2001 |