A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

Hyun Sub Cheong; Du Hak Yoon; Byung Lae Park; Lyoung Hyo Kim; Joon Seol Bae; Sohg Namgoong; Hae Won Lee; Chang Soo Han; Ji On Kim; Il Cheong Cheong; Hyoung Doo Shin

doi:10.1186/1471-2156-9-33

A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

Hyun Sub Cheong, Du Hak Yoon, Byung Lae Park, Lyoung Hyo Kim, Joon Seol Bae, Sohg Namgoong, Hae Won Lee, Chang Soo Han, Ji On Kim, Il Cheong Cheong, Hyoung Doo Shin

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Abstract

Background: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02). Conclusion: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.

Original language	English
Article number	33
Journal	BMC Genetics
Volume	9
DOIs	https://doi.org/10.1186/1471-2156-9-33
State	Published - 19 Apr 2008

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title = "A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle",

abstract = "Background: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02). Conclusion: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.",

author = "Cheong, {Hyun Sub} and Yoon, {Du Hak} and Park, {Byung Lae} and Kim, {Lyoung Hyo} and Bae, {Joon Seol} and Sohg Namgoong and {Won Lee}, Hae and Han, {Chang Soo} and Kim, {Ji On} and Cheong, {Il Cheong} and Shin, {Hyoung Doo}",

year = "2008",

month = apr,

day = "19",

doi = "10.1186/1471-2156-9-33",

language = "English",

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TY - JOUR

T1 - A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

AU - Cheong, Hyun Sub

AU - Yoon, Du Hak

AU - Park, Byung Lae

AU - Kim, Lyoung Hyo

AU - Bae, Joon Seol

AU - Namgoong, Sohg

AU - Won Lee, Hae

AU - Han, Chang Soo

AU - Kim, Ji On

AU - Cheong, Il Cheong

AU - Shin, Hyoung Doo

PY - 2008/4/19

Y1 - 2008/4/19

N2 - Background: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02). Conclusion: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.

AB - Background: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02). Conclusion: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.

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U2 - 10.1186/1471-2156-9-33

DO - 10.1186/1471-2156-9-33

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AN - SCOPUS:44149104109

SN - 1471-2156

VL - 9

JO - BMC Genetics

JF - BMC Genetics

M1 - 33

ER -

A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

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