A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles

Wenlong Xu; Ja Young Park; Krishna Kattel; Badrul Alam Bony; Woo Choul Heo; Seonguk Jin; Jang Woo Park; Yongmin Chang; Ji Yeon Do; Kwon Seok Chae; Tae Jeong Kim; Ji Ae Park; Young Woo Kwak; Gang Ho Lee

doi:10.1039/c2nj40149e

A T₁, T₂ magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles

Wenlong Xu, Ja Young Park, Krishna Kattel, Badrul Alam Bony, Woo Choul Heo, Seonguk Jin, Jang Woo Park, Yongmin Chang, Ji Yeon Do, Kwon Seok Chae, Tae Jeong Kim, Ji Ae Park, Young Woo Kwak, Gang Ho Lee

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Abstract

Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium-europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T₁, T₂ MRI-FI in vitro and in vivo. They had r₁ and r ₂ values of 11.9 and 38.7 s^-1 mM^-1, respectively, and showed clear dose-dependent contrast changes in both R ₁ and R₂ map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla T₁ and T ₂ MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T₁, T₂ MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium-europium oxide nanoparticles.

Original language	English
Pages (from-to)	2361-2367
Number of pages	7
Journal	New Journal of Chemistry
Volume	36
Issue number	11
DOIs	https://doi.org/10.1039/c2nj40149e
State	Published - Nov 2012

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Xu, W., Park, J. Y., Kattel, K., Bony, B. A., Heo, W. C., Jin, S., Park, J. W., Chang, Y., Do, J. Y., Chae, K. S., Kim, T. J., Park, J. A., Kwak, Y. W., & Lee, G. H. (2012). A T₁, T₂ magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles. New Journal of Chemistry, 36(11), 2361-2367. https://doi.org/10.1039/c2nj40149e

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title = "A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles",

abstract = "Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium-europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T1, T2 MRI-FI in vitro and in vivo. They had r1 and r 2 values of 11.9 and 38.7 s-1 mM-1, respectively, and showed clear dose-dependent contrast changes in both R 1 and R2 map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla T1 and T 2 MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T1, T2 MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium-europium oxide nanoparticles.",

author = "Wenlong Xu and Park, \{Ja Young\} and Krishna Kattel and Bony, \{Badrul Alam\} and Heo, \{Woo Choul\} and Seonguk Jin and Park, \{Jang Woo\} and Yongmin Chang and Do, \{Ji Yeon\} and Chae, \{Kwon Seok\} and Kim, \{Tae Jeong\} and Park, \{Ji Ae\} and Kwak, \{Young Woo\} and Lee, \{Gang Ho\}",

year = "2012",

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doi = "10.1039/c2nj40149e",

language = "English",

volume = "36",

pages = "2361--2367",

journal = "New Journal of Chemistry",

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publisher = "Royal Society of Chemistry",

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T1 - A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles

AU - Xu, Wenlong

AU - Park, Ja Young

AU - Kattel, Krishna

AU - Bony, Badrul Alam

AU - Heo, Woo Choul

AU - Jin, Seonguk

AU - Park, Jang Woo

AU - Chang, Yongmin

AU - Do, Ji Yeon

AU - Chae, Kwon Seok

AU - Kim, Tae Jeong

AU - Park, Ji Ae

AU - Kwak, Young Woo

AU - Lee, Gang Ho

PY - 2012/11

Y1 - 2012/11

N2 - Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium-europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T1, T2 MRI-FI in vitro and in vivo. They had r1 and r 2 values of 11.9 and 38.7 s-1 mM-1, respectively, and showed clear dose-dependent contrast changes in both R 1 and R2 map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla T1 and T 2 MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T1, T2 MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium-europium oxide nanoparticles.

AB - Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium-europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T1, T2 MRI-FI in vitro and in vivo. They had r1 and r 2 values of 11.9 and 38.7 s-1 mM-1, respectively, and showed clear dose-dependent contrast changes in both R 1 and R2 map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla T1 and T 2 MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T1, T2 MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium-europium oxide nanoparticles.

UR - https://www.scopus.com/pages/publications/84867515413

U2 - 10.1039/c2nj40149e

DO - 10.1039/c2nj40149e

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SN - 1144-0546

VL - 36

SP - 2361

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JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 11

ER -

A T₁, T₂ magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles

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