Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population

Dong Sun Kim; Seung Ick Cha; Jae Hee Lee; Yu Mi Lee; Jin Eun Choi; Min Jin Kim; Ji Seun Lim; Eung Bae Lee; Chang Ho Kim; Tae In Park; Tae Hoon Jung; Jae Yong Park

doi:10.1016/j.lungcan.2007.04.008

Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population

Dong Sun Kim, Seung Ick Cha, Jae Hee Lee, Yu Mi Lee, Jin Eun Choi, Min Jin Kim, Ji Seun Lim, Eung Bae Lee, Chang Ho Kim, Tae In Park, Tae Hoon Jung, Jae Yong Park

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We performed this study to investigate the aberrant methylation profile of the cancer-related genes in Korean non-small cell lung cancer (NSCLC) that previously exhibited high frequencies of methylation in Western populations. The aberrant promoter methylation of eight genes (GSTP1, p16, FHIT, APC, RASSF1A, hMLH1, hMSH2, AGT) was determined by MSP in 99 surgically resected NSCLCs and their corresponding nonmalignant lung tissues. Methylation in the tumor samples was detected at 15% for GSTP1, 22% for p16, 34% for FHIT1, 48% for APC, 40% for RASSF1A, 18% for hMLH1, 8% for hMSH2 and 21% for AGT, whereas it occurred at lower frequencies in the corresponding nonmalignant lung tissues, particularly in the p16 (1%) and RASSF1A (1%) genes. These results suggest that the methylation profiles of NSCLCs in a Korean population are similar to those in Western populations.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Lung Cancer
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/j.lungcan.2007.04.008
State	Published - Oct 2007

Keywords

Lung cancer
Methylation profiles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2007.04.008

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title = "Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population",

abstract = "We performed this study to investigate the aberrant methylation profile of the cancer-related genes in Korean non-small cell lung cancer (NSCLC) that previously exhibited high frequencies of methylation in Western populations. The aberrant promoter methylation of eight genes (GSTP1, p16, FHIT, APC, RASSF1A, hMLH1, hMSH2, AGT) was determined by MSP in 99 surgically resected NSCLCs and their corresponding nonmalignant lung tissues. Methylation in the tumor samples was detected at 15% for GSTP1, 22% for p16, 34% for FHIT1, 48% for APC, 40% for RASSF1A, 18% for hMLH1, 8% for hMSH2 and 21% for AGT, whereas it occurred at lower frequencies in the corresponding nonmalignant lung tissues, particularly in the p16 (1%) and RASSF1A (1%) genes. These results suggest that the methylation profiles of NSCLCs in a Korean population are similar to those in Western populations.",

keywords = "Lung cancer, Methylation profiles",

author = "Kim, {Dong Sun} and Cha, {Seung Ick} and Lee, {Jae Hee} and Lee, {Yu Mi} and Choi, {Jin Eun} and Kim, {Min Jin} and Lim, {Ji Seun} and Lee, {Eung Bae} and Kim, {Chang Ho} and Park, {Tae In} and Jung, {Tae Hoon} and Park, {Jae Yong}",

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AU - Kim, Dong Sun

AU - Cha, Seung Ick

AU - Lee, Jae Hee

AU - Lee, Yu Mi

AU - Choi, Jin Eun

AU - Kim, Min Jin

AU - Lim, Ji Seun

AU - Lee, Eung Bae

AU - Kim, Chang Ho

AU - Park, Tae In

AU - Jung, Tae Hoon

AU - Park, Jae Yong

PY - 2007/10

Y1 - 2007/10

N2 - We performed this study to investigate the aberrant methylation profile of the cancer-related genes in Korean non-small cell lung cancer (NSCLC) that previously exhibited high frequencies of methylation in Western populations. The aberrant promoter methylation of eight genes (GSTP1, p16, FHIT, APC, RASSF1A, hMLH1, hMSH2, AGT) was determined by MSP in 99 surgically resected NSCLCs and their corresponding nonmalignant lung tissues. Methylation in the tumor samples was detected at 15% for GSTP1, 22% for p16, 34% for FHIT1, 48% for APC, 40% for RASSF1A, 18% for hMLH1, 8% for hMSH2 and 21% for AGT, whereas it occurred at lower frequencies in the corresponding nonmalignant lung tissues, particularly in the p16 (1%) and RASSF1A (1%) genes. These results suggest that the methylation profiles of NSCLCs in a Korean population are similar to those in Western populations.

AB - We performed this study to investigate the aberrant methylation profile of the cancer-related genes in Korean non-small cell lung cancer (NSCLC) that previously exhibited high frequencies of methylation in Western populations. The aberrant promoter methylation of eight genes (GSTP1, p16, FHIT, APC, RASSF1A, hMLH1, hMSH2, AGT) was determined by MSP in 99 surgically resected NSCLCs and their corresponding nonmalignant lung tissues. Methylation in the tumor samples was detected at 15% for GSTP1, 22% for p16, 34% for FHIT1, 48% for APC, 40% for RASSF1A, 18% for hMLH1, 8% for hMSH2 and 21% for AGT, whereas it occurred at lower frequencies in the corresponding nonmalignant lung tissues, particularly in the p16 (1%) and RASSF1A (1%) genes. These results suggest that the methylation profiles of NSCLCs in a Korean population are similar to those in Western populations.

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KW - Methylation profiles

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Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population

Abstract

Keywords

UN SDGs

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