Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique

Ji Young Song; Seong Gon Kim; Jong Won Lee; Weon Sik Chae; Haeyong Kweon; You Young Jo; Kwang Gill Lee; Yong Chan Lee; Je Yong Choi; Jwa Young Kim

doi:10.1016/j.tripleo.2011.05.002

Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique

Ji Young Song, Seong Gon Kim, Jong Won Lee, Weon Sik Chae, Haeyong Kweon, You Young Jo, Kwang Gill Lee, Yong Chan Lee, Je Yong Choi, Jwa Young Kim

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47 Scopus citations

Abstract

Objective: The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane. Study design: Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery. Results: FT-IR showed that the conformation of the SF membrane was a random coil structure and that SM1 was the least soluble. When SM1 was used in the animal model, the groups with SM1 had significantly higher new bone formation than the uncovered control in both the μ-CT and the histomorphometric analyses (P <.05). Conclusions: The SF membrane had more new bone formation compared with the uncovered control.

Original language	English
Pages (from-to)	e26-e33
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	112
Issue number	6
DOIs	https://doi.org/10.1016/j.tripleo.2011.05.002
State	Published - Dec 2011

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10.1016/j.tripleo.2011.05.002

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title = "Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique",

abstract = "Objective: The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane. Study design: Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery. Results: FT-IR showed that the conformation of the SF membrane was a random coil structure and that SM1 was the least soluble. When SM1 was used in the animal model, the groups with SM1 had significantly higher new bone formation than the uncovered control in both the μ-CT and the histomorphometric analyses (P <.05). Conclusions: The SF membrane had more new bone formation compared with the uncovered control.",

author = "Song, {Ji Young} and Kim, {Seong Gon} and Lee, {Jong Won} and Chae, {Weon Sik} and Haeyong Kweon and Jo, {You Young} and Lee, {Kwang Gill} and Lee, {Yong Chan} and Choi, {Je Yong} and Kim, {Jwa Young}",

year = "2011",

month = dec,

doi = "10.1016/j.tripleo.2011.05.002",

language = "English",

volume = "112",

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T1 - Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique

AU - Song, Ji Young

AU - Kim, Seong Gon

AU - Lee, Jong Won

AU - Chae, Weon Sik

AU - Kweon, Haeyong

AU - Jo, You Young

AU - Lee, Kwang Gill

AU - Lee, Yong Chan

AU - Choi, Je Yong

AU - Kim, Jwa Young

PY - 2011/12

Y1 - 2011/12

N2 - Objective: The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane. Study design: Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery. Results: FT-IR showed that the conformation of the SF membrane was a random coil structure and that SM1 was the least soluble. When SM1 was used in the animal model, the groups with SM1 had significantly higher new bone formation than the uncovered control in both the μ-CT and the histomorphometric analyses (P <.05). Conclusions: The SF membrane had more new bone formation compared with the uncovered control.

AB - Objective: The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane. Study design: Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery. Results: FT-IR showed that the conformation of the SF membrane was a random coil structure and that SM1 was the least soluble. When SM1 was used in the animal model, the groups with SM1 had significantly higher new bone formation than the uncovered control in both the μ-CT and the histomorphometric analyses (P <.05). Conclusions: The SF membrane had more new bone formation compared with the uncovered control.

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IS - 6

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Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique

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