Acetylated resveratrol and oxyresveratrol suppress uvb-induced mmp-1 expression in human dermal fibroblasts

Jae Eun Lee, Jijeong Oh, Daeun Song, Mijeong Lee, Dongyup Hahn, Yong Chool Boo, Nam Joo Kang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Resveratrol (RES) and oxyresveratrol (OXYRES) are considered and utilized as active ingredients of anti-aging skin cosmetics. However, these compounds are susceptible to oxidative discoloration and unpleasant odor in solutions, limiting their use in cosmetics. Accordingly, RES and OXYRES were chemically modified to acetylated derivatives with enhanced stability, and their anti-aging effect on the skin and detailed molecular mechanism of their acetylated derivatives were investigated. Acetylated RES and OXYRES lost their acetyl group and exerted an inhibitory effect on H2O2-induced ROS levels in human dermal fibroblast (HDF) cells. In addition, RES, OXYRES, and their acetylated derivatives suppressed UVB-induced matrix metalloproteinase (MMP)-1 expression via inhibition of mitogen-activated protein kinases (MAPKs) and Akt/mTOR signaling pathways. Furthermore, RES, OXYRES, and their acetylated derivatives suppressed type I collagen in TPA-treated HDF cells. Collectively, these results suggest the beneficial effects and underlying molecular mechanisms of RES, OXYRES, and their acetylated derivatives for anti-skin aging applications.

Original languageEnglish
Article number1252
JournalAntioxidants
Volume10
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Acetylated derivative
  • Matrix metalloproteinase-1
  • Oxyresveratrol
  • Resveratrol
  • Skin aging
  • Type I collagen
  • Ultraviolet B

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